Plasma lipoproteins and coronary heart disease

Both plasma low-density (LDL) and high-density lipoproteins (HDL) have been associated with the genesis of cardiovascular disease. Recent studies with cells grown in culture have suggested a regularory role of these lipoproteins in cellular cholesterol metabolism and pointed at abnormalities resulting from deviations of these regulatory processes. The precise relationship between these observations in vitro and the atherogenic process remains open to investigation.