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Related Concept Videos

Cirrhosis II: Pathophysiology01:24

Cirrhosis II: Pathophysiology

Cirrhosis is a progressive chronic liver injury caused by prolonged inflammation, excessive fibrotic remodeling, and impaired regeneration. Over time, repeated hepatic insults disrupt the liver’s architecture and function, leading to reduced blood flow, impaired bile drainage, and diminished metabolic capacity.Pathophysiology of cirrhosisCirrhosis arises from three main responses to chronic liver damage: inflammation, immune activation, and hepatocyte death. These processes lead to structural...
Liver Regeneration01:24

Liver Regeneration

The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
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Cirrhosis I: Introduction01:23

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Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
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Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

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Stem Cell Culture

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Related Experiment Video

Updated: Jun 12, 2026

Isolation of CD133+ Liver Stem Cells for Clonal Expansion
12:06

Isolation of CD133+ Liver Stem Cells for Clonal Expansion

Published on: October 10, 2011

Stem cells and hepatic cirrhosis.

Z Chen1, L Z Qi, R Zeng

  • 1Laboratory of Infection and Immunology, Affiliated Hospital of Luzhou Medical College, Luzhou, Sichuan, China.

Panminerva Medica
|June 3, 2010
PubMed
Summary

Stem cell therapy offers a promising alternative for treating liver cirrhosis, complementing or replacing damaged cells and correcting matrix imbalances. This review explores various stem cells, focusing on adult stem cells for potential clinical applications in liver repair.

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Last Updated: Jun 12, 2026

Isolation of CD133+ Liver Stem Cells for Clonal Expansion
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Published on: February 18, 2017

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Serum Free Production of Three-dimensional Human Hepatospheres from Pluripotent Stem Cells

Published on: July 20, 2019

Area of Science:

  • Regenerative Medicine
  • Hepatology
  • Stem Cell Biology

Background:

  • Hepatic cirrhosis, characterized by fibrosis and regenerative nodules, leads to portal hypertension and end-stage liver disease.
  • Current treatments like liver transplantation are limited by donor organ scarcity.
  • Stem cell research presents a promising avenue for alternative therapies in chronic liver disease.

Purpose of the Study:

  • To review the characteristics and therapeutic potential of various stem cells for liver repair.
  • To explore stem cell-based strategies for complementing or replacing damaged hepatocytes and correcting extracellular matrix abnormalities in cirrhosis.
  • To highlight the potential of autologous adult stem cells for clinical application in treating hepatic fibrogenesis.

Main Methods:

  • Review of preclinical studies and scientific literature on stem cell therapies for liver cirrhosis.
  • Analysis of the mechanisms of hepatic fibrogenesis and stem cell interactions.
  • Examination of different stem cell types, including hepatocytes, liver progenitor cells, hematopoietic stem cells, mesenchymal stem cells, embryonic stem cells, and induced pluripotent stem cells.

Main Results:

  • Various stem cells possess regenerative potential for liver tissue.
  • Stem cell therapies can address both cellular damage and matrix dysregulation in cirrhosis.
  • Autologous adult stem cells show significant promise due to fewer clinical application obstacles.

Conclusions:

  • Stem cell-based treatments hold significant therapeutic potential for hepatic cirrhosis.
  • Further research into stem cell mechanisms, particularly autologous adult stem cells, is crucial for clinical translation.
  • Cellular and molecular interventions targeting hepatic fibrogenesis are key to successful stem cell therapy for cirrhosis.