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Stereological and Flow Cytometry Characterization of Leukocyte Subpopulations in Models of Transient or Permanent Cerebral Ischemia
12:42

Stereological and Flow Cytometry Characterization of Leukocyte Subpopulations in Models of Transient or Permanent Cerebral Ischemia

Published on: December 28, 2014

[Leukocytosis and outcomes of acute stroke]

B I Kuznik, I Iu Morozova, O S Rodnina

    Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
    |June 3, 2010
    PubMed

    We carried out the retrospective analysis of 300 disease histories of patients with stroke hospitalized in the first 24 h of the disease. The presence of leukocytosis and its severity were evaluated as predictors of outcome. The level of leukocyte-erythrocyte aggregations in the blood film was determined in some patients. The analysis revealed that the higher was leukocytosis, the more severe was the course of stroke and the higher was frequency of fatal outcomes. Patients with stroke more often had neutrophilic leukocytosis than monocytosis, the former was the predictor of worse prognosis. The most unfavorable prognosis was observed in patients with hemorrhagic stroke and leukocytosis. The higher was the number of leukocytes, the higher was the probability of fatal outcome in the first month of stroke. The level of leukocyte-erythrocyte aggregations dramatically increased in the blood of stroke patients that promoted the disturbance of microcirculation and worsened significantly the disease prognosis.

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