The State of Microcirculatory Hemodynamics in Patients with Moderate and Severe COVID-19
B I Kuznik1, Yu N Smolyakov2, Yu K Shapovalov1
1Chita State Medical Academy, Ministry of Health of the Russian Academy, Chita, Russia.
Insights
Microcirculatory hemodynamic indexes (HI) were altered in moderate and severe COVID-19 patients. Severe COVID-19 showed a depressed low-frequency index (HI1), indicating decompensated microcirculatory disturbances.
Area of Science:
- Cardiovascular Science
- Infectious Disease Research
- Medical Physiology
Background:
- COVID-19 significantly impacts systemic hemodynamics.
- Microcirculatory dysfunction is increasingly recognized as a key factor in COVID-19 severity.
- Understanding microcirculatory changes is crucial for managing COVID-19 patients.
Purpose of the Study:
- To evaluate microcirculatory hemodynamic indexes (HI) in patients with moderate and severe COVID-19.
- To identify specific microcirculatory alterations associated with disease severity.
- To assess the compensatory mechanisms in microcirculation during COVID-19.
Main Methods:
- Assessment of microcirculatory hemodynamic indexes (HI) including absolute spectral indexes (HI1, HI2, HI3) and frequency ratios (HI1/HI3).
- Analysis of oscillatory indices (MAYER1-3, RESP1-3).
- Comparison of HI between patients with moderate and severe COVID-19.
Main Results:
- Both moderate and severe COVID-19 groups exhibited increased spectral indexes (HI1, HI2, HI3) and the HI1/HI3 ratio.
- Severe COVID-19 patients showed a significantly lower low-frequency index (HI1) compared to moderate cases.
- Oscillatory indices (MAYER1-3, RESP1-3) were reduced in both patient groups.
- Disease aggravation correlated with a decrease in the low-frequency index (HI1).
Conclusions:
- Microcirculatory disturbances are evident in both moderate and severe COVID-19.
- Severe COVID-19 is characterized by decompensated microcirculatory processes, particularly a depressed low-frequency index (HI1).
- While moderate COVID-19 shows compensatory regulatory shifts, severe cases indicate a failure of these mechanisms.
Abstract:
Microcirculatory hemodynamic indexes (HI) were assessed in patients with moderate and severe COVID-19. In both groups, a significant increase in the absolute spectral indexes (HI1, HI2, and HI3) and the ratio of low-frequency to high-frequency component (HI1/HI3) was revealed. In the group of severe infection, only the "slow" index (low-frequency HI1) of microcirculatory hemodynamics was significantly lower. The oscillatory indices MAYER1-3 and RESP1-3 were reduced in patients of both groups. The aggravation of the disease course was accompanied by depression of the low-frequency index HI1. Regulatory shifts compensate for disturbances in microcirculatory processes in moderate COVID-19, but severe course was associated with their decompensation.
