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[Changes in high density lipoproteins in peripheral vascular disease]
J Pedro-Botet1, M Sentí, X Nogués
1Departamento de Medicina, Hospital del Mar, Barcelona.
Medicina Clinica
|April 6, 1991
Summary
High-density lipoprotein cholesterol (HDL-C) is a key indicator for peripheral vascular disease (PVD). Lower HDL-C levels correlate with increased severity of lower limb ischemia in PVD patients.
Area of Science:
- Cardiovascular Medicine
- Lipidology
- Vascular Biology
Background:
- Lipid and lipoprotein disturbances are implicated in atherosclerosis development.
- Changes in high-density lipoprotein (HDL) composition in peripheral vascular disease (PVD) and their link to lower limb ischemia severity require clarification.
Purpose of the Study:
- To investigate HDL composition changes in PVD patients.
- To determine the relationship between HDL composition and the severity of lower limb ischemia.
Main Methods:
- Study included 102 men with PVD and 100 age-sex-matched controls.
- Collected data on smoking history and measured serum lipids, HDL-cholesterol, HDL-proteins, apoprotein A-I, and HDL-triglycerides.
- Assessed ischemia severity using the arm-ankle pressure index.
Main Results:
- PVD patients exhibited higher serum triglycerides and lower HDL-cholesterol and HDL-proteins compared to controls.
- Smoker patients with PVD had elevated triglycerides and reduced HDL-cholesterol.
- A significant decrease in HDL-cholesterol was observed with increasing severity of lower limb ischemia.
Conclusions:
- HDL-cholesterol is identified as the primary marker for PVD.
- The severity of ischemia in PVD is directly associated with reduced HDL-cholesterol levels.
- Apolipoprotein A-I was not found to be a risk marker for PVD in this study.