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Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

[A cutaneous thickening case...].

S Serra¹, C Ambrósio, M João Salvador

¹Serviço de Reumatologia, Hospitais da Universidade de Coimbra, Coimbra. saramserra@hotmail.com

Acta Reumatologica Portuguesa

|June 4, 2010

Summary

This summary is machine-generated.

This case study details a rare scleroderma-like skin disease, Scleromyxedema, diagnosed in a 79-year-old female. The condition presented as progressive skin thickening and was confirmed through clinical examination and skin biopsy.

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Area of Science:

Dermatology
Rheumatology
Internal Medicine

Background:

Scleromyxedema is a rare, acquired, diffuse cutaneous sclerosis characterized by mucin deposition in the dermis.
It is often associated with a monoclonal gammopathy, typically IgG kappa.

Observation:

A 79-year-old female presented with a 6-year history of progressive cutaneous thickening affecting the face, trunk, and limbs.
She also experienced exertional dyspnea and intermittent solid dysphagia.
Laboratory findings included IgG kappa monoclonal protein and speckled pattern antinuclear antibodies; nailfold capillaroscopy was normal.

Findings:

Clinical examination and cutaneous histopathology confirmed the diagnosis of Scleromyxedema.
The histopathology revealed characteristic mucin deposition and fibroblast proliferation.

Implications:

This case highlights the importance of considering Scleromyxedema in the differential diagnosis of cutaneous sclerosis.
Early recognition and diagnosis are crucial for managing this rare condition and its potential systemic manifestations.