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Homeostatic Imbalance

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Homeostasis is the maintenance of a stable internal environment within the body, which is crucial for the proper functioning of cells, tissues, organs, and organ systems. The body has various control mechanisms that work together to regulate various physiological parameters such as temperature, blood pressure, pH balance, and fluid balance, to name a few. These control mechanisms are based on feedback loops that can be either positive or negative.
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Related Experiment Video

Updated: Jun 12, 2026

Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans

Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans

Published on: September 7, 2021

Frailty and the homeostatic network.

Stefania Bandinelli¹, Anna Maria Corsi, Yuri Milaneschi

¹Geriatric Unit, Azienda Sanitaria di Firenze. bandinelli@asf.toscana.it

Acta Bio-Medica : Atenei Parmensis

|June 4, 2010

Summary

Frailty in older adults accelerates decline and disrupts homeostasis, increasing health risks. Research explores biological markers beyond mobility to understand this complex aging syndrome.

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Area of Science:

Gerontology and Aging Research
Physiology and Homeostasis
Biomarker Discovery

Background:

Aging exhibits significant individual variability in health and function.
Frailty in older adults involves accelerated decline in functional reserve and failing compensatory mechanisms.
Current frailty identification relies on mobility and motor performance, but biological markers are emerging.

Purpose of the Study:

To explore the concept of frailty as an age-related physiological and pathological alteration.
To investigate emerging candidate biological markers for frailty syndrome.
To examine theories on aging, performance decline, and homeostatic dysregulation.

Main Methods:

Literature review of frailty syndrome conceptualization.
Analysis of theories on aging and loss of performance ability.
Exploration of homeostatic network dysregulation with age.

Main Results:

Frailty is characterized by a constellation of signs and symptoms resulting from age-related physiological and pathological changes.
Emerging research suggests biological markers may offer more specific identification of frailty.
A prominent hypothesis links frailty to progressive age-related dysregulation of the homeostatic network.

Conclusions:

Frailty represents a significant challenge in aging populations, impacting health outcomes.
Understanding the biological underpinnings of frailty is crucial for effective interventions.
The homeostatic network's efficiency is a key area for future research in aging and frailty.