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Related Concept Videos

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Amebiasis01:28

Amebiasis

Entamoeba histolytica, a protozoan parasite, is responsible for intestinal and extraintestinal amebiasis. Though a significant proportion of infections remain asymptomatic, approximately 50 million individuals annually are estimated to present with clinical disease, resulting in up to 100,000 deaths globally. The disease burden is disproportionately high in regions with lower socioeconomic status, such as parts of India, Africa, Mexico, and Latin America.Etiology and TransmissionThe infective...
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...

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Related Experiment Video

Updated: Jun 12, 2026

Real-time Quaking-induced Conversion Assay for Detection of CWD Prions in Fecal Material
09:50

Real-time Quaking-induced Conversion Assay for Detection of CWD Prions in Fecal Material

Published on: September 29, 2017

Faecal CWD prion excretion and inflammation.

Giovanni Di Guardo1, Giuseppe Marruchella

  • 1University of Teramo, Faculty of Veterinary Medicine, Department of Comparative Biomedical Sciences, Teramo, Italy. gdiguardo@unite.it

The New Microbiologica
|June 4, 2010
PubMed
Summary

Chronic wasting disease (CWD) prions are shed in feces. Gut inflammation may increase prion infectivity and fecal shedding rates in mule deer, impacting CWD transmission dynamics.

Area of Science:

  • Veterinary Neurology
  • Wildlife Disease Ecology
  • Prion Biology

Background:

  • Chronic wasting disease (CWD) is a significant prion disease affecting deer populations in North America.
  • Recent studies indicate prion infectivity in the feces of CWD-infected mule deer.
  • Understanding CWD transmission routes is crucial for wildlife management.

Purpose of the Study:

  • To investigate the role of gut inflammation in modulating CWD prion infectivity.
  • To assess the impact of inflammation on CWD prion fecal excretion rates.

Main Methods:

  • Analysis of pre-clinical evidence of prion infectivity in fecal material.
  • Consideration of inflammatory conditions within the gastrointestinal tract.

Main Results:

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Detection of Abnormal Prion Protein by Immunohistochemistry

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Last Updated: Jun 12, 2026

Real-time Quaking-induced Conversion Assay for Detection of CWD Prions in Fecal Material
09:50

Real-time Quaking-induced Conversion Assay for Detection of CWD Prions in Fecal Material

Published on: September 29, 2017

Monitoring Immune Cells Trafficking Fluorescent Prion Rods Hours after Intraperitoneal Infection
09:22

Monitoring Immune Cells Trafficking Fluorescent Prion Rods Hours after Intraperitoneal Infection

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Detection of Abnormal Prion Protein by Immunohistochemistry
06:38

Detection of Abnormal Prion Protein by Immunohistochemistry

Published on: May 5, 2023

  • Pre-clinical evidence suggests prion shedding in feces.
  • Gut inflammation is hypothesized to influence prion infectivity titers.
  • Inflammation may consequently affect the rate of CWD prion fecal excretion.

Conclusions:

  • Gut inflammatory conditions may play a role in CWD transmission.
  • Further research is needed to confirm the link between gut inflammation and prion shedding.
  • Modulating gut inflammation could be a potential strategy for CWD management.