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Updated: Jun 12, 2026

Preparation, Administration, and Assessment of In Vivo Tissue-Specific Cellular Uptake of Fluorescent Dye-Labeled Liposomes
Published on: July 30, 2020
[Study on optimizing prescription of baicalein long circulating liposomes]
1Guangdong Food and Drug Vocational College, Guangzhou 510520, China.
Objective:
To optimize the prescription of baicalein long circulating liposomes (Baicalein LCLs).
Methods:
The liposomes were prepared by the reverse evaporating method. The entrapment efficiency and the carrying amount were determined by HPLC-Sephadex method. The main influencing factors were identified by single factor analysis, then the techniques of the prescription and preparation of liposomes were optimized by orthogonal experiment.
Results:
The best prescription was as follows: The proportionality of cholesterin to lecithin was 1 : 2; The dosage of PEG 4 000 was 2 mg; The proportionality of water phase to oil phase was 1 : 2; The dosage of baicalein was 30 mg.
Conclusion:
After optimized, the average entrapment efficiency of liposomes is 81.42% and the average carrying amount is 32.25%.
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