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Related Concept Videos

Phases of Wound Repair01:28

Phases of Wound Repair

Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...

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Related Experiment Video

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Expansion of Two-dimension Electrospun Nanofiber Mats into Three-dimension Scaffolds
06:14

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Published on: January 7, 2019

Nanofibrous materials for wound care.

Wen Zhong1, Malcolm M Q Xing, Howard I Maibach

  • 1Department of Textile Sciences, University of Manitoba, Winnipeg, Canada. zhong@cc.umanitoba.ca

Cutaneous and Ocular Toxicology
|June 4, 2010
PubMed
Summary

Nanofibrous membranes show promise for wound care as drug carriers. Research explores natural and synthetic polymers for these dressings, evaluating their performance and safety.

Area of Science:

  • Biomaterials Science
  • Wound Healing Research
  • Polymer Chemistry

Background:

  • Nanofibrous membranes offer high surface area for therapeutic agent delivery.
  • They are soft materials suitable for wound dressing applications.
  • Current research focuses on optimizing their properties for wound care.

Purpose of the Study:

  • To overview research and development of nanofibrous dressing materials for wound care.
  • To discuss natural and synthetic polymers used in their fabrication.
  • To describe evaluation methods for performance and cytotoxicity.

Main Methods:

  • Review of existing literature on nanofibrous membranes for wound care.
  • Analysis of natural and synthetic polymers for dressing fabrication.

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Synthesis of Keratin-based Nanofiber for Biomedical Engineering
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Expansion of Two-dimension Electrospun Nanofiber Mats into Three-dimension Scaffolds
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  • Description of in vitro and in vivo testing methodologies.

    • Main Results:

    • Nanofibrous membranes are effective carriers for antibacterial and wound-healing agents.
    • Natural polymers are generally less cytotoxic but have lower mechanical strength than synthetic polymers.
    • Blending or crosslinking natural polymers with synthetic ones can improve mechanical properties but may affect biocompatibility.

    Conclusions:

    • Nanofibrous membranes hold significant potential for advanced wound care applications.
    • Careful selection and modification of polymers are crucial for balancing efficacy, safety, and mechanical integrity.
    • Further research is needed to optimize biocompatibility and performance of these advanced wound dressings.