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Updated: Jun 12, 2026

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
Published on: September 6, 2017
HLA polymorphisms in Sindhi community in Mumbai, India
S Chhaya1, S Desai, D Saranath
1Dhirubhai Ambani LifeSciences Center, R-282, TTC Area of MIDC, Thane Belapur Road, Rabale, Navi-Mumbai, Mumbai, Maharashtra, India. sonalu@rediffmail.com
This study analyzed Human Leukocyte Antigen (HLA) allele and haplotype frequencies in the Sindhi population, comparing them with other Indian ethnic groups. Findings aid in developing an Indian umbilical cord stem cell panel for transplantation.
Area of Science:
- Immunogenetics
- Population Genetics
- Molecular Anthropology
Background:
- The Indian population exhibits significant ethnic and linguistic diversity, influencing genetic profiles.
- Understanding Human Leukocyte Antigen (HLA) polymorphisms is crucial for transplantation and population studies.
Purpose of the Study:
- To investigate HLA-A, B, and DRB1 allele and haplotype frequencies in the Sindhi population.
- To compare these frequencies with Marathi, Gujarati, and North Indian populations.
- To contribute to establishing an umbilical cord stem cell panel in India.
Main Methods:
- Analysis of HLA-A, B, and DRB1 polymorphisms in 413 cord blood samples.
- Utilized polymerase chain reaction with sequence-specific primer amplification.
- Phylogenetic analysis using neighbour-joining trees based on DA genetic distances.
Main Results:
- Common HLA alleles identified across groups include A*01, A*02, A*11, A*24, B*35, B*40, DRB1*07, and DRB1*15.
- HLA-DRB1*03 showed significantly higher frequency in the Sindhi population.
- Phylogenetic analysis clustered Sindhis with North Indian and Pakistan Sindhi groups.
- Common three-locus haplotypes (A*02-B*40-DRB1*15, A*33-B*44-DRB1*07) suggest Caucasian and Oriental influences.
Conclusions:
- The study provides valuable HLA profile data for the Sindhi and related Indian populations.
- Results support the development of a diverse Indian umbilical cord stem cell panel.
- Findings have clinical implications for unrelated umbilical cord stem cell transplantation in India.
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