Related Experiment Video
Updated: Jun 12, 2026
07:29
Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
Chromoblastomycosis associated with a lethal squamous cell carcinoma
Edoardo Torres1, Javier Gil Beristain, Zahide Lievanos
1Hospital General Dr. Manuel Gea González, Cidade do México, México. rarenas98@hotmail.com
Anais Brasileiros De Dermatologia
|June 4, 2010
Summary
Chromoblastomycosis, a fungal infection, can lead to squamous cell carcinoma in chronic cases. This report details a 72-year-old man with a 30-year history of this infection who developed skin cancer.
Area of Science:
- Medical Mycology
- Dermatology
- Oncology
Background:
- Chromoblastomycosis is a chronic fungal infection affecting subcutaneous tissues.
- It is caused by dematiaceous fungi like Fonsecaea, Phialophora, and Cladophialophora.
- Complications include secondary infections, lymphedema, and rarely, associated malignancies.
Observation:
- A 72-year-old male presented with a 30-year history of chromoblastomycosis.
- The infection was located in the gluteal region.
- The patient subsequently developed squamous cell carcinoma.
Findings:
- Chronic chromoblastomycosis can transform into squamous cell carcinoma.
- This case highlights a rare but serious complication of long-standing fungal infections.
Implications:
- Early detection and management of chromoblastomycosis are crucial to prevent complications.
- Further research into the oncogenic potential of chromoblastomycosis is warranted.
- This case underscores the importance of monitoring chronic infections for malignant changes.
Related Concept Videos
01:30Skin Cancer
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
01:27Cryptococcal Meningitis
Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
01:03Rous Sarcoma Virus (RSV) and Cancer
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
01:06Induced Pluripotent Stem Cells
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...
Somatic cells are...