Related Experiment Video
Updated: Jun 12, 2026
13:05
Enzymatic Synthesis of Epoxidized Metabolites of Docosahexaenoic, Eicosapentaenoic, and Arachidonic Acids
Published on: June 28, 2019
Eudesmanolides and methyl ester derivatives from Dimerostemma arnottii
Sérgio Ricardo Ambrosio1, Ricardo Stefani, Vladimir Constantino Gomes Heleno
1Nutcleo de Pesquisas em Ciências Exatas e Tecnológicas, Universidade de Franca, 14404-600, Franca, SP, Brazil.
Natural Product Communications
|June 5, 2010
Summary
Phytochemical analysis of Dimerostemma arnottii revealed novel eudesmane derivatives. These findings support previous phylogenetic studies, highlighting the plant family Asteraceae
Area of Science:
- Phytochemistry
- Natural Products Chemistry
- Plant Taxonomy
Background:
- Dimerostemma species are known sources of bioactive compounds.
- Previous phylogenetic studies suggest close relationships within the Dimerostemma genus.
Purpose of the Study:
- To conduct a phytochemical investigation of Dimerostemma arnottii.
- To isolate and elucidate the structures of new compounds.
- To assess the chemotaxonomic relevance of the findings.
Main Methods:
- Phytochemical analysis of Dimerostemma arnottii.
- Structure elucidation using 1D and 2D Nuclear Magnetic Resonance (NMR) spectroscopy.
- High-Resolution Electrospray Ionization Mass Spectrometry (HR-ESI-MS) analysis.
Main Results:
- Isolation of a known eudesmanolide.
- Identification of two unusual eudesmane methyl ester derivatives.
- Discovery of a new eudesmanolide.
- Structural similarity observed between eudesmanes from D. arnottii and other Dimerostemma species.
Conclusions:
- The isolated compounds contribute to the understanding of Dimerostemma chemical diversity.
- The structural similarities support existing phylogenetic data for the genus.
- The study provides chemotaxonomic insights into the Asteraceae family.
Related Concept Videos
01:28Adrenergic Agonists: Mixed-Action Agents
Mixed-action adrenergic agonists, like ephedrine and pseudoephedrine, directly and indirectly affect adrenergic receptors. These agents stimulate adrenoceptors and indirectly release stored neurotransmitters, amplifying the adrenergic response.
Ephedrine and pseudoephedrine lack a catecholamine group, making them less susceptible to degradation by metabolic enzymes. They have increased oral bioavailability and lipophilicity, resulting in a longer duration of action. Their response is reduced by...
Ephedrine and pseudoephedrine lack a catecholamine group, making them less susceptible to degradation by metabolic enzymes. They have increased oral bioavailability and lipophilicity, resulting in a longer duration of action. Their response is reduced by...
01:22Direct-Acting Cholinergic Agonists: Chemistry and Structure-Activity Relationship
Cholinergic agonists or cholinomimetics mimic the action of acetylcholine to stimulate the parasympathetic nervous system. They are categorized into direct-acting and indirect-acting agents. The direct-acting cholinergic drugs induce the parasympathetic response by directly binding to the muscarinic or nicotine receptors. In comparison, the indirect-acting cholinergic drugs prevent acetylcholine hydrolysis, indirectly contributing to the extended parasympathetic response.
The direct-acting...
The direct-acting...
01:29Cholinergic Antagonists: Chemistry and Structure-Activity Relationship
Cholinergic antagonists bind to cholinergic receptors and limit the effects of acetylcholine and other cholinergic agonists. Based on the specific cholinergic receptor affinity, these antagonists are classified as muscarinic or nicotinic. Anticholinergics interrupt parasympathetic innervations while sympathetic innervations remain uninterrupted. Muscarinic antagonists are also called 'muscarinic antagonists', 'antimuscarinics', or 'parasympatholytics'. Nicotinic antagonists are called...
01:14Alkylation of β-Diester Enolates: Malonic Ester Synthesis
Malonic ester synthesis is a method to obtain α substituted carboxylic acids from ꞵ-diesters such as diethyl malonate and alkyl halides.
01:20Antiasthma Drugs: Muscarinic Receptor Antagonists
Muscarinic receptor antagonists, also known as antimuscarinic agents, are a class of bronchodilators used to treat asthma, although they are more commonly used to treat COPD. They work by inhibiting the action of acetylcholine (ACh), a neurotransmitter, on muscarinic receptors found in the airways.
Antimuscarinic agents compete with ACh for the same binding site on the muscarinic receptors. By binding to these receptors, they inhibit the downstream effects of ACh and block the parasympathetic...
Antimuscarinic agents compete with ACh for the same binding site on the muscarinic receptors. By binding to these receptors, they inhibit the downstream effects of ACh and block the parasympathetic...
01:16Adrenergic Agonists: Chemistry and Structure-Activity Relationship
Adrenergic agonists' structure-activity relationship (SAR) determines their selectivity and efficacy. These agonists comprise a phenylethylamine moiety with an aromatic ring and an ethylamine side chain.
Aromatic ring substitutions: Substituting the aromatic ring with –OH groups at positions 3 and 4 yields catecholamines (e.g., epinephrine), which have a high affinity for adrenoceptors. Hydrogen bonding between –OH groups and receptors enhances adrenergic activity.
Separation of the aromatic...
Aromatic ring substitutions: Substituting the aromatic ring with –OH groups at positions 3 and 4 yields catecholamines (e.g., epinephrine), which have a high affinity for adrenoceptors. Hydrogen bonding between –OH groups and receptors enhances adrenergic activity.
Separation of the aromatic...