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Published on: April 1, 2019
Linkage disequilibrium of polymorphic RAET1 genes in Thais
S Rareongjai1, A Romphruk, A V Romphruk
1Biomedical Sciences Program, Graduate School, Khon Kaen University, Khon Kaen, Thailand.
Tissue Antigens
|June 5, 2010
Summary
This study investigated genetic variations in RAET1 genes, finding strong linkage disequilibrium between RAET1E and RAET1G in the Thai population. These findings provide foundational data on RAET1 gene polymorphisms and haplotypes.
Area of Science:
- Immunogenetics
- Molecular Biology
- Population Genetics
Background:
- Retinoic acid early transcripts-1 (RAET1) proteins, also known as UL-16 binding proteins (ULBPs), function as ligands for the NKG2D receptor on immune cells.
- NKG2D receptor activation by RAET1 ligands triggers immune responses against tumor and viral-infected cells.
- Limited information exists regarding the genetic polymorphism of the RAET1 gene cluster.
Purpose of the Study:
- To analyze the linkage disequilibrium between four polymorphic RAET1 genes (RAET1E, RAET1G, RAET1H, RAET1L).
- To identify potential RAET1 haplotypes in an unrelated Thai population.
Main Methods:
- Analysis of genetic linkage disequilibrium among RAET1E, RAET1G, RAET1H, and RAET1L.
- Genotyping was performed on 318 unrelated Thai individuals.
Main Results:
- The strongest linkage disequilibrium was observed between RAET1E and RAET1G (P-value <5.0 x 10(-5), D'=0.707, r(2)=0.840).
- Specific allelic combinations (RAET1E(*)001 with RAET1G(*)002, and RAET1E(*)002 with RAET1G(*)001) were found to be in linkage disequilibrium.
- Two major RAET1 haplotypes with frequencies exceeding 10% were identified: RAET1E(*)001; RAET1G(*)002; RAET1H(*)001; RAET1L(*)001 and RAET1E(*)002; RAET1G(*)001; RAET1H(*)002; RAET1L(*)003.
Conclusions:
- This study establishes fundamental data on RAET1 gene polymorphisms within the Thai population.
- The identified RAET1 haplotypes offer insights into the genetic structure of this important immune-related gene cluster.
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