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Updated: Jun 12, 2026
08:30
Murine Isolated Heart Model of Myocardial Stunning Associated with Cardioplegic Arrest
Published on: August 6, 2015
Peritoneal dialysis is not associated with myocardial stunning
Nicholas M Selby1, Christopher W McIntyre
1Department of Renal Medicine, Royal Derby Hospital, Derby, UK. nick.selby@nhs.net
Summary
Peritoneal dialysis (PD) exchanges do not appear to cause subclinical myocardial ischemia, unlike hemodialysis. This study found no significant cardiac abnormalities in patients undergoing PD, suggesting it may be safer for the heart.
Area of Science:
- Cardiology
- Nephrology
- Physiology
Background:
- Hemodialysis can cause subclinical myocardial ischemia, leading to cardiac failure and poor prognosis.
- Peritoneal dialysis (PD) also involves hemodynamic changes and is linked to cardiovascular disease.
Purpose of the Study:
- To investigate if peritoneal dialysis (PD) exchanges induce subclinical myocardial ischemia.
- To assess left ventricular (LV) regional wall motion abnormalities (RWMAs) after a PD exchange.
Main Methods:
- Prospective observational study of 10 PD patients.
- Serial echocardiography to evaluate LV ejection fraction and regional systolic function.
- Continuous pulse wave analysis for blood pressure and hemodynamic variables.
Main Results:
- Very low frequency of RWMA development (5/100 regions); 6 patients had no RWMAs.
- Mean shortening fraction significantly increased post-exchange in 2-chamber and 4-chamber views.
- Minor changes in mean arterial pressure driven by peripheral resistance fluctuations during dialysate exchange.
Conclusions:
- Acute effects of PD exchanges do not lead to subclinical myocardial ischemia.
- This contrasts with the known effects of hemodialysis on cardiac function.
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