Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Molecules with Multiple Chiral Centers02:25

Molecules with Multiple Chiral Centers

Molecules that possess multiple chiral centers can afford a large number of stereoisomers. For instance, while some molecules like 2-butanol have one chiral center, defined as a tetrahedral carbon atom with four different substituents attached, several molecules like butane-2,3-diol have multiple chiral centers. A simple formula to predict the number of stereoisomers possible for a molecule with n chiral centers is 2n. However, there can be a lower number where some of the stereoisomers are...
Prochirality02:05

Prochirality

The concept of prochirality leads to the nomenclature of the individual faces of a molecule and plays a crucial role in the enantioselective reaction. It is a concept where two or more achiral molecules react to produce chiral products. A typical process is the reaction of an achiral ketone to generate a chiral alcohol. Here, the achiral reactant reacts with an achiral reducing agent, sodium borohydride, to generate an equimolar mixture of the chiral enantiomers of the product. For example, an...
Chirality02:25

Chirality

Chirality is a term that describes the lack of mirror symmetry in an object. In other words, chiral objects cannot be superposed on their mirror images. For example, our feet are chiral, as the mirror image of the left foot, the right foot, cannot be superposed on the left foot.
Chiral objects exhibit a sense of handedness when they interact with another chiral object. For example, our left foot can only fit in the left shoe and not in the right shoe. Achiral objects — objects that have...
Chirality at Nitrogen, Phosphorus, and Sulfur02:30

Chirality at Nitrogen, Phosphorus, and Sulfur

Chirality is most prevalent in carbon-based tetrahedral compounds, but this important facet of molecular symmetry extends to sp3-hybridized nitrogen, phosphorus and sulfur centers, including trivalent molecules with lone pairs. Here, the lone pair behaves as a functional group in addition to the other three substituents to form an analogous tetrahedral center that can be chiral.
A consequence of chirality is the need for enantiomeric resolution. While this is theoretically possible for all...
Metal-Ligand Bonds02:51

Metal-Ligand Bonds

The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
Properties of Organometallic Compounds01:23

Properties of Organometallic Compounds

Organometallic compounds are compounds that contain a carbon–metal bond. Carbon belongs to an organyl group like alkyl, aryl, allyl, or benzyl groups. The metal can be from Group I or Group II of the periodic table, a transition metal, or a semimetal.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dual Metalation Site Zr-Metal-Organic Frameworks: Controlled Synthesis of Metal-Organic Framework-Bound Proximal Metal Complexes.

Inorganic chemistry·2026
Same author

A ZrO<sub><i>x</i></sub>H<sub><i>y</i></sub>-Templated UiO-66 Composite as a Heterogeneous Nanozyme for Site-Specific Myoglobin Proteolysis.

ACS applied materials & interfaces·2026
Same author

Rhodium Carbonyl Complexes within the Tunable Microenvironments of UiO-66 Analogues.

Inorganic chemistry·2025
Same author

Pressure-Driven Loading of Large Guests in Metal-Organic Frameworks.

ACS nano·2025
Same author

Pronounced Catalytic Enhancement through Phase Partitioned Metal-Organic Framework Gas Shuttles.

Journal of the American Chemical Society·2025
Same author

Understanding the Role of the Zr-MOF Support Structure on Templated Ternary CO<sub>2</sub> Hydrogenation Catalyst Structure and Activity.

ACS applied materials & interfaces·2025

Related Experiment Video

Updated: Jun 12, 2026

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks (MOFs)
08:25

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks (MOFs)

Published on: January 17, 2020

Metal-organic frameworks with designed chiral recognition sites.

Cory Valente1, Eunwoo Choi, Matthew E Belowich

  • 1Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA.

Chemical Communications (Cambridge, England)
|June 5, 2010
PubMed
Summary

Chiral recognition sites were precisely integrated into metal-organic frameworks using Cram-like bisbinaphthyl[22]crown-6 struts and zinc oxide joints. This creates highly ordered, designed frameworks for advanced molecular interactions.

More Related Videos

Synthesis and Characterization of Functionalized Metal-organic Frameworks
11:27

Synthesis and Characterization of Functionalized Metal-organic Frameworks

Published on: September 5, 2014

Experimental Approaches for the Synthesis of Low-Valent Metal-Organic Frameworks from Multitopic Phosphine Linkers
07:14

Experimental Approaches for the Synthesis of Low-Valent Metal-Organic Frameworks from Multitopic Phosphine Linkers

Published on: May 12, 2023

Related Experiment Videos

Last Updated: Jun 12, 2026

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks (MOFs)
08:25

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks (MOFs)

Published on: January 17, 2020

Synthesis and Characterization of Functionalized Metal-organic Frameworks
11:27

Synthesis and Characterization of Functionalized Metal-organic Frameworks

Published on: September 5, 2014

Experimental Approaches for the Synthesis of Low-Valent Metal-Organic Frameworks from Multitopic Phosphine Linkers
07:14

Experimental Approaches for the Synthesis of Low-Valent Metal-Organic Frameworks from Multitopic Phosphine Linkers

Published on: May 12, 2023

Area of Science:

  • Supramolecular Chemistry
  • Materials Science
  • Crystallography

Background:

  • Metal-organic frameworks (MOFs) are porous materials with diverse applications.
  • Chiral recognition is crucial for enantioselective synthesis and separation.
  • Designing MOFs with specific recognition sites remains a challenge.

Purpose of the Study:

  • To synthesize novel chiral metal-organic frameworks.
  • To incorporate precise chiral recognition sites within the MOF structure.
  • To investigate the structural order and design of the resulting frameworks.

Main Methods:

  • Utilizing Cram-like bisbinaphthyl[22]crown-6 as chiral linking struts.
  • Employing Zn(4)O(CO(2))(6) secondary building units (SBUs) for framework assembly.
  • Single-crystal X-ray diffraction for structural characterization.

Main Results:

  • Successfully linked chiral struts with inorganic joints to form highly ordered MOFs.
  • Demonstrated precise placement of chiral recognition sites throughout the crystal lattice.
  • The resulting MOFs exhibit designed supramolecular architecture.

Conclusions:

  • The synthetic strategy enables the rational design of MOFs with embedded chiral recognition.
  • Precise control over the placement of chiral sites is achieved.
  • These findings open avenues for advanced chiral separation and catalysis using MOFs.