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Related Concept Videos

Distributed Loads01:19

Distributed Loads

Distributed loads are a common type of load that engineers and scientists encounter in various practical situations. Distributed loads often refer to a type of load spread over a surface or a structure and can be modeled as continuous force per unit area.
For example, consider a bookshelf filled with books stacked vertically adjacent to each other. The weight of the books is evenly distributed over the length of the shelf. As a result, the pressure at different locations on the surface of the...
Frames01:30

Frames

Frames are essential components of various mechanical and structural systems used daily. These structures are known for their stability and ability to bear heavy loads. A frame is constructed using two-force and multi-force members, interconnected using pin joints. In contrast, trusses are made entirely of two-force members.
Frames are versatile and widely used in various applications such as structural supports for beams and columns, automobile chassis construction, and in the construction...
Frames: Problem Solving I01:24

Frames: Problem Solving I

Consider a jib crane with an external load suspended from the pulley. The dimensions of the crane members are shown in the figure. A systematic analysis of the frame structure is required to determine the reaction forces at the pin joints, assuming that the pulleys are frictionless.
Frames: Problem Solving II01:26

Frames: Problem Solving II

Consider a hydraulic hoist supporting a load of 1 kN. Assuming a simplified schematic representation of this frame structure, the force acting on BD and BF members can be determined.
Bearing Stress01:22

Bearing Stress

Bearing stress refers to the contact pressure between two separate bodies. To visualize this, imagine a bolt thrust through a plate. The bolt applies a force to the plate, which exerts an equal but opposite force back onto the bolt. This force isn't just a singular entity but a compilation of numerous smaller forces distributed across the contact surface between the bolt and the plate.
Due to the intricacy of these microforces, an average value, known as bearing stress, is often used by...
Stress: General Loading Conditions01:15

Stress: General Loading Conditions

To grasp the intricacy of real-world conditions where multiple loads are applied simultaneously to a structure, one might visualize a section passing through a specific point within a body, aligned parallel to the xy plane. This section is subjected to various forces, including original loads, normal forces, and shearing forces.
The shearing force, possessing potential directionality within the plane of the section, is simplified into two component forces running parallel to the x and y axes.

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Related Experiment Video

Updated: May 18, 2026

Synthesis and Characterization of Functionalized Metal-organic Frameworks
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Pressure-Driven Loading of Large Guests in Metal-Organic Frameworks.

Lu Tang1, Connor W Edwards2, Konstantin Stracke2

  • 1School of Physical Science and Technology, ShanghaiTech University, Shanghai 201210, China.

ACS Nano
|October 22, 2025
PubMed
Summary

Researchers developed a pressure-enhanced method to load bulky molecules into metal-organic frameworks (MOFs) with small pores. This technique enables high-capacity encapsulation for diverse applications like catalysis and drug delivery.

Keywords:
MOFsdrug encapsulation and releasepressure-induced encapsulation

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Area of Science:

  • Materials Science
  • Chemical Engineering

Background:

  • Metal-organic frameworks (MOFs) are used to confine guest molecules for heterogenized applications.
  • Loading bulky molecules into MOFs with small apertures remains a challenge.

Purpose of the Study:

  • To develop a general and efficient strategy for loading bulky organic molecules into MOFs with small apertures.
  • To demonstrate the use of pressure to overcome aperture size limitations in MOFs.

Main Methods:

  • Applied external pressure to facilitate the diffusion of guest molecules into UiO-66 and UiO-66-NH2 MOFs.
  • Investigated the loading mechanism under pressure, including MOF cavity and guest molecule rearrangements.

Main Results:

  • Pressure enables rapid and high-capacity loading of liquids or meltable solids into MOFs, even with sub-aperture guests.
  • Identified pressure-induced local geometric rearrangements as key to guest confinement.
  • Successfully encapsulated a wide range of guest molecules.

Conclusions:

  • Pressure-assisted loading is an effective strategy for incorporating bulky guests into MOFs with small pores.
  • This method broadens the scope of MOF applications in areas such as heterogeneous catalysis, postsynthetic modifications, and drug release.