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Related Experiment Video

Updated: May 16, 2026

Microfluidic Fabrication of Core-Shell Microcapsules carrying Human Pluripotent Stem Cell Spheroids
10:51

Microfluidic Fabrication of Core-Shell Microcapsules carrying Human Pluripotent Stem Cell Spheroids

Published on: October 13, 2021

Emerging porous materials for cell encapsulation.

Francesco Carraro1, Miriam de J Velásquez-Hernández1, Anita Emmerstorfer-Augustin2

  • 1Institute of Physical and Theoretical Chemistry, Graz University of Technology, Stremayrgasse 9, Graz, 8010, Austria. paolo.falcaro@tugaz.at.

Chemical Society Reviews
|May 14, 2026
PubMed
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This summary is machine-generated.

This review explores cell composites (cell@MOF, cell@COF, cell@HOF) for synthetic biology. It covers synthesis, viability assessment, and applications like cell therapy and biocatalysis, highlighting future prospects.

Area of Science:

  • Materials Science
  • Synthetic Biology
  • Biotechnology

Background:

  • Recent advancements in porous framework materials like metal-organic frameworks (MOFs), covalent-organic frameworks (COFs), and hydrogen-bonded organic frameworks (HOFs) have enabled novel composite designs.
  • Integrating biological components (cells) with these abiotic exoskeletons offers new avenues for engineered biological systems.

Purpose of the Study:

  • To review the progress in cell@MOF, cell@COF, and cell@HOF composites.
  • To outline synthetic strategies for porous abiotic exoskeletons and discuss cell surface chemistry.
  • To examine major applications and future prospects in synthetic cell engineering.

Main Methods:

  • Focus on framework-based materials synthesis.
  • Discussion of cell surface chemistry and viability assessment methods.

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Last Updated: May 16, 2026

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Cellular Encapsulation in 3D Hydrogels for Tissue Engineering
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  • Review of composite preparation and characterization techniques.
  • Main Results:

    • Key synthetic strategies for porous abiotic exoskeletons are outlined.
    • Cell surface chemistry and viability assessment methods are discussed.
    • Major applications including cell therapy, biocatalysis, biosensing, and CO2 mitigation are examined.

    Conclusions:

    • Cell@MOF, cell@COF, and cell@HOF composites represent a promising frontier in synthetic biology and materials science.
    • Framework materials offer significant potential for engineering synthetic cells and enhancing cellular functions.
    • Further research is needed to address challenges in composite preparation, characterization, and application development.