Related Experiment Video

Updated: Jun 12, 2026

Investigating von Willebrand Factor Pathophysiology Using a Flow Chamber Model of von Willebrand Factor-platelet String Formation
08:30

Investigating von Willebrand Factor Pathophysiology Using a Flow Chamber Model of von Willebrand Factor-platelet String Formation

Published on: August 14, 2017

[Homocysteine and von Willebrand factor in chronic alcoholism]

A M Koriakin, N N Epifantseva, I V Dadyka

    Klinicheskaia Laboratornaia Diagnostika
    |June 8, 2010
    PubMed

    Insights

    Chronic alcoholism elevates homocysteine (HC) and von Willebrand factor (VWF) levels, increasing cardiovascular risk. These factors, though not correlated, indicate significant vascular damage in alcoholic patients.

    Area of Science:

    • Cardiovascular Medicine
    • Clinical Biochemistry
    • Addiction Medicine

    Context:

    • Chronic alcoholism is a significant public health concern.
    • Cardiovascular disease risk is elevated in alcoholic populations.
    • Biomarkers like homocysteine and VWF are implicated in cardiovascular pathology.

    Purpose:

    • To investigate the levels of homocysteine (HC) and von Willebrand factor (VWF) in patients with Stage II chronic alcoholism.
    • To assess the potential role of HC and VWF as cardiovascular risk factors in this population.

    Summary:

    • Forty-one male patients with Stage II chronic alcoholism were studied.
    • Elevated plasma homocysteine (HC) levels were observed in 63.4% of patients compared to controls.
    • Increased content and activity of von Willebrand factor (VWF) were found in 80.6% of patients.
    • No correlation was found between HC and VWF levels.

    Impact:

    • Findings suggest that hyperhomocysteinemia and elevated VWF contribute to increased cardiovascular risk in chronic alcoholism.
    • Vascular endothelial damage is likely exacerbated by these factors.
    • Highlights the need for monitoring cardiovascular risk in individuals with chronic alcoholism.

    More Related Videos

    Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder05:12

    Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

    Published on: June 23, 2023

    Assessment of Glutamine as a Fuel Source for Alveolar Macrophages Exposed to Chronic Ethanol Using an Extracellular Flux Bioanalyzer08:37

    Assessment of Glutamine as a Fuel Source for Alveolar Macrophages Exposed to Chronic Ethanol Using an Extracellular Flux Bioanalyzer

    Published on: November 15, 2024

    Related Concept Videos

    Cirrhosis II: Pathophysiology01:24

    Cirrhosis II: Pathophysiology

    Cirrhosis is a progressive chronic liver injury caused by prolonged inflammation, excessive fibrotic remodeling, and impaired regeneration. Over time, repeated hepatic insults disrupt the liver’s architecture and function, leading to reduced blood flow, impaired bile drainage, and diminished metabolic capacity.Pathophysiology of cirrhosisCirrhosis arises from three main responses to chronic liver damage: inflammation, immune activation, and hepatocyte death. These processes lead to structural...
    Chronic Pancreatitis II: Pathophysiology01:21

    Chronic Pancreatitis II: Pathophysiology

    Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...
    Disorders of Hemostasis01:24

    Disorders of Hemostasis

    Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
    Thromboembolic Disorders
    Two factors primarily cause thromboembolic conditions.
    Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

    Anticoagulant Drugs: Low-Molecular-Weight Heparins

    Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
    Extrinsic and Intrinsic Pathways of Hemostasis01:20

    Extrinsic and Intrinsic Pathways of Hemostasis

    Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
    The Extrinsic Pathway
    The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which forms a...
    Chronic Pancreatitis I: Introduction01:25

    Chronic Pancreatitis I: Introduction

    Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...