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Suicidal Isoniazid poisoning
Haji Khan Khoharo1, Shuaib Ansari, Allauddin Abro
1Department of Medicine, Muhammad Medical College Hospital, Mirpurkhas, Pakistan. drhajikhan786@gmail.com
Journal of Ayub Medical College, Abbottabad : JAMC
|June 8, 2010
Summary
Isoniazid poisoning, often from overdose, can cause seizures and coma. Prompt treatment with pyridoxine (vitamin B6) is crucial for managing severe poisoning and preventing fatal outcomes.
Area of Science:
- Toxicology
- Neurology
- Emergency Medicine
Background:
- Isoniazid is a common antituberculosis drug.
- Isoniazid overdose can lead to severe neurological and metabolic complications.
- Pyridoxine (vitamin B6) is a known antidote for Isoniazid toxicity.
Observation:
- A case of suicidal Isoniazid overdose is presented.
- The patient experienced intractable grand mal seizures.
- Symptoms manifested within hours of ingestion.
Findings:
- Ingestion of >80 mg/kg Isoniazid causes severe central nervous system symptoms.
- A dose of 125 mg/kg is potentially lethal without prompt treatment.
- Seizures were controlled with diazepam and supportive care.
Implications:
- Highlights the critical role of early recognition and management of Isoniazid poisoning.
- Reinforces the efficacy of pyridoxine as an antidote in severe cases.
- Emphasizes the need for immediate medical intervention following significant Isoniazid overdose.
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