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Protein Folding Quality Check in the RER

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Updated: Jun 12, 2026

Ex utero Electroporation and Whole Hemisphere Explants: A Simple Experimental Method for Studies of Early Cortical Development
13:47

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Published on: April 3, 2013

Emerging topics in Reelin function.

Eckart Förster1, Hans H Bock, Joachim Herz

  • 1Institut für Anatomie I: Zelluläre Neurobiologie, Hamburg, Germany. efoerste@uke.uni-hamburg.de

The European Journal of Neuroscience
|June 8, 2010
PubMed
Summary
This summary is machine-generated.

Reelin signaling guides neuronal migration and brain development. This review details Reelin

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Molecular Biology

Background:

  • Reelin signaling is crucial for cortical neuron development, influencing migration, dendrite maturation, and synaptic function.
  • Understanding Reelin's downstream signaling cascade is key to deciphering its diverse roles in the brain.
  • Lipoprotein receptors Apoer2 and Vldlr are known mediators of Reelin binding.

Purpose of the Study:

  • To review the distinct functions of Reelin receptors Apoer2 and Vldlr in cortical development.
  • To discuss the role of n-cofilin as a downstream effector in neuronal migration.
  • To explore the Reelin-Notch signaling crosstalk and Reelin's role in hippocampal development.

Main Methods:

  • Review of existing literature on Reelin signaling pathways.
  • Analysis of studies investigating Reelin receptors and downstream effectors.
  • Discussion of recent findings on Reelin's function in the developing and adult brain.

Main Results:

  • Reelin receptors Apoer2 and Vldlr have distinct roles in cortical layer formation.
  • n-cofilin regulates actin dynamics essential for neuronal migration.
  • Reelin signaling interacts with Notch signaling and influences hippocampal development.

Conclusions:

  • Reelin signaling is a complex cascade with multifaceted roles throughout brain development and in mature synaptic function.
  • Further characterization of Reelin's downstream effectors and signaling crosstalk is vital for understanding brain development and function.
  • Reelin plays a significant role in the formation of the dentate radial glial scaffold and synaptic modulation in the adult brain.