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Updated: Jun 12, 2026

A Platform of Anti-biofilm Assays Suited to the Exploration of Natural Compound Libraries

A Platform of Anti-biofilm Assays Suited to the Exploration of Natural Compound Libraries

Published on: December 27, 2016

Biofilms.

Jeffrey D Suh¹, Vijay Ramakrishnan, James N Palmer

¹Department of Otorhinolaryngology-Head and Neck Surgery, Hospital of the University of Pennsylvania, Ravdin Building 5th Floor, 3400 Spruce Street, Philadelphia, PA 19104, USA.

Otolaryngologic Clinics of North America

|June 8, 2010

Summary

This summary is machine-generated.

Bacterial biofilms, microbial communities in chronic infections, may cause difficult-to-treat chronic sinusitis. New therapies targeting these biofilms are being explored for better treatment outcomes.

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Published on: January 20, 2011

Area of Science:

Microbiology
Infectious Diseases
Otolaryngology

Background:

Bacterial biofilms are implicated in numerous chronic infections.
Recalcitrant chronic sinusitis cases may involve bacterial biofilms.
Traditional treatments often fail in biofilm-associated chronic sinusitis.

Purpose of the Study:

To explore the role of bacterial biofilms in chronic sinusitis.
To investigate novel therapeutic strategies for biofilm-associated chronic rhinosinusitis.

Main Methods:

Review of current evidence on bacterial biofilms in chronic sinusitis.
Discussion of potential novel therapeutic approaches.

Main Results:

Growing evidence suggests bacterial biofilms contribute to chronic sinusitis.
Current therapies may be insufficient against biofilm-related infections.

Conclusions:

Bacterial biofilms are a significant factor in some chronic sinusitis cases.
Novel therapies are needed to prevent and destabilize biofilms.
Further research is required to evaluate topical antimicrobials, surfactants, and adjuvant therapies for biofilm-associated chronic rhinosinusitis.