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Related Experiment Video

Updated: Jun 12, 2026

A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma

A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma

Published on: January 5, 2017

Perineural involvement: what does it mean?

Arash Ronaghy¹, Ron Yaar, Lynne J Goldberg

¹Department of Dermatology, Dermatopathology Section, Boston University School of Medicine, 609 Albany Street, Boston, MA 02118, USA.

The American Journal of Dermatopathology

|June 8, 2010

Summary

Perineural invasion in skin lesions can indicate malignancy and aggressive behavior. However, some benign growths can mimic this, highlighting the need for careful diagnosis to avoid overtreatment.

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Area of Science:

Dermatology
Surgical Pathology
Oncology

Background:

Perineural invasion is a key factor in local spread for malignant cutaneous neoplasms.
It correlates with aggressive tumor behavior, recurrence, and increased mortality.
The term 'invasion' is strongly linked to malignancy.

Purpose of the Study:

To review benign cutaneous and noncutaneous neoplasms that demonstrate or mimic perineural involvement.
To differentiate benign perineural involvement from malignant invasion.
To prevent diagnostic confusion and overly aggressive treatment of benign lesions.

Main Methods:

Literature review of benign neoplasms and reactive conditions with perineural involvement.
Comparative analysis of benign lesions with and without perineural involvement.
Histopathological examination and case series review.

Main Results:

Certain benign neoplasms and reactive lesions can show perineural involvement or mimic it.
Benign perineural involvement does not correlate with aggressive behavior.
Histopathological features can help distinguish benign from malignant perineural processes.

Conclusions:

Recognition of benign conditions mimicking perineural involvement is crucial.
Accurate diagnosis prevents misdiagnosis and unnecessary aggressive treatment.
Careful histopathological evaluation is key to differentiating benign perineural involvement from malignant invasion.