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Obesity is not associated with contrast nephropathy
Navin Jaipaul1, Rendell Manalo, Seyed-Ali Sadjadi
1Section of Nephrology, VA Loma Linda Healthcare System.
Therapeutics and Clinical Risk Management
|June 8, 2010
Summary
Obesity is not an independent risk factor for contrast-induced nephropathy (CIN), a type of acute kidney injury (AKI) or contrast nephropathy (CN), following radiocontrast media exposure. This study found no significant association between body mass index (BMI) and CIN development.
Area of Science:
- Nephrology
- Radiology
- Public Health
Background:
- Radiocontrast media can cause acute kidney injury (AKI) and contrast nephropathy (CN), increasing morbidity and mortality.
- Inflammatory mediators may play a role in contrast-induced nephropathy (CIN) pathogenesis.
- The independent association between obesity and CIN is not well-established.
Purpose of the Study:
- To investigate if obesity, stratified by body mass index (BMI), is an independent risk factor for CIN.
- The study focused on a large, hemodynamically stable population of hospitalized U.S. veterans.
Main Methods:
- Retrospective chart review of hospitalized U.S. veterans.
- Assessed the presence of AKI or CN after intravenous radiocontrast administration.
- Compared patient characteristics between those who developed CIN and those who did not.
Main Results:
- The prevalence of AKI was 16.1% and CN was 12.6%.
- Patients with CIN were older and more likely to be diabetic.
- Obesity, stratified by BMI, was not associated with the development of AKI or CN.
Conclusions:
- Obesity does not appear to be an independent risk factor for CIN.
- Further research may be needed to explore other potential contributing factors to CIN in obese individuals.
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