Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Jun 12, 2026

Polymer Microarrays for High Throughput Discovery of Biomaterials

Polymer Microarrays for High Throughput Discovery of Biomaterials

Published on: January 25, 2012

Polybasic Nanomatrices Prepared By UV-initiated Photopolymerization.

Omar Z Fisher¹, Nicholas A Peppas

¹Department of Biomedical Engineering, University of Texas at Austin, 1 University Station C0400, Austin, TX 78712-1062 USA.

|June 8, 2010

Summary

Researchers developed novel nanoscale polymer networks using photoinitiated emulsion polymerization. These pH-responsive nanomatrices show potential for drug delivery and imaging applications.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Recent advances in intraoral, buccal and sublingual drug delivery systems and technologies.

Journal of controlled release : official journal of the Controlled Release Society·2026

Same author

Systematic design of polybasic nanogels: influence of hydrophobic monomers on tunable physicochemical and biological properties.

npj biomedical innovations·2026

Same author

33 Unresolved Questions in Nanoscience and Nanotechnology.

ACS nano·2025

Same author

Rational Design of PEGylated Nanogels: Optimization of Degree of PEGylation and Development of a Novel Enzyme-Responsive Grafted Layer.

International journal of pharmaceutics·2025

Same author

Drug Delivery Technologies for the Treatment of Age-Related Macular Degeneration.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2025

Same author

Designing the Next Generation of Biomaterials through Nanoengineering.

Advanced materials (Deerfield Beach, Fla.)·2025

Area of Science:

Polymer Chemistry
Materials Science
Nanotechnology

Background:

Nanoscale polymer networks are crucial for advanced applications.
Developing materials that respond to specific stimuli, like pH, is an active research area.
Controlled synthesis of nanostructures with tunable properties remains a challenge.

Purpose of the Study:

To describe a novel method for synthesizing pH-responsive nanoscale polymer networks.
To characterize these nanomatrices for potential use in drug delivery, imaging, and sensing.
To investigate the influence of crosslinking density on nanomatrix properties.

Main Methods:

Photoinitiated emulsion polymerization was employed for synthesis.
Poly[2-(diethylamino)ethyl methacrylate] core with poly(ethylene glycol) surface grafting was utilized.

More Related Videos

Controlled Synthesis and Fluorescence Tracking of Highly Uniform Poly(N-isopropylacrylamide) Microgels

Controlled Synthesis and Fluorescence Tracking of Highly Uniform Poly(N-isopropylacrylamide) Microgels

Published on: September 8, 2016

Polymeric Microneedle Array Fabrication by Photolithography

Polymeric Microneedle Array Fabrication by Photolithography

Published on: November 17, 2015

Related Experiment Videos

Last Updated: Jun 12, 2026

Polymer Microarrays for High Throughput Discovery of Biomaterials

Polymer Microarrays for High Throughput Discovery of Biomaterials

Published on: January 25, 2012

Controlled Synthesis and Fluorescence Tracking of Highly Uniform Poly(N-isopropylacrylamide) Microgels

Controlled Synthesis and Fluorescence Tracking of Highly Uniform Poly(N-isopropylacrylamide) Microgels

Published on: September 8, 2016

Polymeric Microneedle Array Fabrication by Photolithography

Polymeric Microneedle Array Fabrication by Photolithography

Published on: November 17, 2015

Crosslinking density was varied to control mesh size, surface charge, and encapsulation efficiency.

Main Results:

Synthesized nanomatrices (50-150 nm) swell in acidic media.
Increased crosslinking density enabled imaging via scanning electron microscopy and controlled encapsulation of insulin and gold nanoparticles.
Nanocomposite matrix behavior was confirmed through inorganic phase sequestration and aggregation control.

Conclusions:

The developed method provides tunable nanoscale polymer networks with pH-responsive properties.
These nanomatrices demonstrate significant potential as versatile platforms for drug delivery, bioimaging, and sensing devices.
The ability to control nanomatrix characteristics opens avenues for tailored material design.