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Cost-effectiveness of antiplatelet therapy for secondary stroke prevention

Darya Malinina1, Carla Zema, Stephen Sander

  • 1HeartDrug Research Laboratories, Johns Hopkins University, MD, USA.

Expert Review of Pharmacoeconomics & Outcomes Research
|June 10, 2010
PubMed

Insights

Antiplatelet therapy is recommended for preventing secondary vascular events after stroke or transient ischemic attack. This review assesses the cost-effectiveness of aspirin, dipyridamole, and clopidogrel for this purpose.

Area of Science:

  • Neurology
  • Cardiology
  • Pharmacoeconomics

Background:

  • Current guidelines recommend antiplatelet therapy over anticoagulants for secondary stroke prevention.
  • Aspirin is a widely used, cost-effective antiplatelet agent.
  • Other recommended agents include extended-release dipyridamole plus aspirin and clopidogrel.

Purpose of the Study:

  • To evaluate the cost-effectiveness of various antiplatelet agents for secondary stroke prevention.
  • To understand the socioeconomic value of recommended antiplatelet strategies.

Main Methods:

  • Review of existing literature on antiplatelet therapies for secondary stroke prevention.
  • Analysis of cost-effectiveness data for aspirin, dipyridamole/aspirin, and clopidogrel.

Main Results:

  • Aspirin offers a balance of prevention benefit and low cost.
  • Extended-release dipyridamole plus aspirin and clopidogrel represent alternative antiplatelet strategies.
  • The cost-effectiveness of these agents is crucial for socioeconomic value assessment.

Conclusions:

  • Understanding the cost-effectiveness of antiplatelet agents is vital for optimizing secondary stroke prevention strategies.
  • Informed choices regarding antiplatelet therapy can enhance socioeconomic value in stroke management.

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