MQScore_SNP software for multipoint parametric linkage analysis of quantitative traits in large pedigrees
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Updated: Jun 12, 2026

Large-Scale Multi-Omics Genome-Wide Association Studies (Mo-GWAS): Guidelines for Sample Preparation and Normalization
Published on: July 27, 2021
Tatiana I Axenovich1, Yurii S Aulchenko
1Institute of Cytology & Genetics, Siberian Division, Russian Academy of Sciences, Novosibirsk, 630090, Russia. aks@bionet.nsc.ru
Abstract:
We describe software for multipoint parametric linkage analysis of quantitative traits using information about SNP genotypes. A mixed model of major gene and polygene inheritance is implemented in this software. Implementation of several algorithms to avoid computational underflow and decrease running time permits application of our software to the analysis of very large pedigrees collected in human genetically isolated populations. We tested our software by performing linkage analysis of adult height in a large pedigree from a Dutch isolated population. Three significant and four suggestive loci were identified with the help of our programs, whereas variance-component-based linkage analysis, which requires the pedigree fragmentation, demonstrated only three suggestive peaks. The software package MQScore_SNP is available at http://mga.bionet.nsc.ru/soft/index.html.
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