Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Movement Joints in Buildings01:27

Movement Joints in Buildings

Movement joints in buildings are essential design elements that accommodate inevitable motions caused by various factors such as temperature changes, moisture content variations, and structural deflections. These motions, if not considered in design and construction, can lead to unsightly or dangerous damage. Movement joints are incorporated in different forms to manage these stresses and allow materials to move without causing distress.
The simplest type of movement joints, working joints, are...
Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
Development of the Limb Synovial Joints01:07

Development of the Limb Synovial Joints

Joints form during embryonic development in conjunction with the formation and growth of the associated bones. The embryonic tissue that gives rise to all bones, cartilage, and connective tissues of the body is called mesenchyme.
The mesenchymal stem cells differentiate into chondrocytes that form the hyaline cartilage, and later the cartilaginous model of the bone. This model further transforms into a bone. This process is known as endochondral ossification.
During development, the limbs...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Lumber01:19

Lumber

Lumber is derived from logs which are harvested, debarked, and processed into long pieces with a rectangular cross-section. The transformation of logs into lumber involves multiple steps, beginning with an automated saw that slices the log into slabs. These slabs are then transported via a conveyor belt to smaller saws, where they are cut into square-edged pieces of specific widths.
Initially, the surfaces of these lumber pieces are rough, and their dimensions may vary slightly from one end to...
Lumber Defects01:23

Lumber Defects

Lumber defects, which can affect both the appearance and structural integrity of wood, include a variety of growth and manufacturing flaws. Growth defects such as knots and knotholes occur where branches were once attached to the tree trunk, with knotholes forming when these knots fall out. Other natural defects include decay and insect damage, which compromise the wood's strength and durability.
Shakes are minor fractures that run along or across the wood's annual rings, while wane is...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

High-precision mass and <math><msup><mi>β</mi> <mo>-</mo></msup></math> decay <i>Q</i>-value measurement of <math><mmultiscripts><mrow></mrow> <mrow></mrow> <mn>129</mn></mmultiscripts></math> Sb and its isomer.

The European physical journal. A, Hadrons and nuclei·2026
Same author

Demographics of epithelioid trophoblastic tumour and placental site trophoblastic tumour: a 21 year UK population study.

Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology·2025
Same author

The Tandem Reconnection and Cusp Electrodynamics Reconnaissance Satellites (TRACERS) Science Operations Center.

Space science reviews·2025
Same author

Creating Novel Standards for Datapoints on an Elective Orthopaedic Theatre List Document.

Malaysian orthopaedic journal·2024
Same author

Soft sensor for viable cell counting by measuring dynamic oxygen uptake rate.

New biotechnology·2024
Same author

Prognostic value of EndoPredict test in patients with hormone receptor-positive, human epidermal growth factor receptor 2-negative primary breast cancer screened for the randomized, double-blind, phase III UNIRAD trial.

ESMO open·2024

Related Experiment Video

Updated: Jun 12, 2026

Chicken Recombinant Limbs Assay to Understand Morphogenesis, Patterning, and Early Steps in Cell Differentiation
08:08

Chicken Recombinant Limbs Assay to Understand Morphogenesis, Patterning, and Early Steps in Cell Differentiation

Published on: January 12, 2022

New house or new limbs?!

I Nwachuku1, N Obi, P Housden

  • 1East Kent NHS Trust, Kent, UK. iheanyi@doctors.net.uk

Annals of the Royal College of Surgeons of England
|June 10, 2010
PubMed
Summary

This case study shows recombinant factor VIIa enabling major surgery for severe hemophilia with inhibitors. The treatment offers improved quality of life and reduced long-term care needs despite high initial costs.

Area of Science:

  • Orthopaedic Surgery
  • Haematology
  • Pharmacology

Background:

  • Severe haemophilia (factor VIII deficiency) often leads to end-stage joint disease.
  • Patients with inhibitors to factor VIII present significant treatment challenges for orthopaedic interventions.

Observation:

  • A rare case of end-stage haemophiliac joint disease with factor VIII inhibitors is presented.
  • The patient received treatment with recombinant factor VIIa.

Findings:

  • Recombinant factor VIIa facilitated major orthopaedic procedures previously unattainable.
  • Successful surgery, prosthetic fitting, and rehabilitation were achieved.

Implications:

  • This approach offers a pathway for managing complex orthopaedic cases in patients with haemophilia and inhibitors.

More Related Videos

Assessing Forelimb Function after Unilateral Cervical SCI using Novel Tasks: Limb Step-alternation, Postural Instability and Pasta Handling
08:11

Assessing Forelimb Function after Unilateral Cervical SCI using Novel Tasks: Limb Step-alternation, Postural Instability and Pasta Handling

Published on: September 16, 2013

Generation of Chimeric Axolotls with Mutant Haploid Limbs Through Embryonic Grafting
07:17

Generation of Chimeric Axolotls with Mutant Haploid Limbs Through Embryonic Grafting

Published on: January 29, 2020

Related Experiment Videos

Last Updated: Jun 12, 2026

Chicken Recombinant Limbs Assay to Understand Morphogenesis, Patterning, and Early Steps in Cell Differentiation
08:08

Chicken Recombinant Limbs Assay to Understand Morphogenesis, Patterning, and Early Steps in Cell Differentiation

Published on: January 12, 2022

Assessing Forelimb Function after Unilateral Cervical SCI using Novel Tasks: Limb Step-alternation, Postural Instability and Pasta Handling
08:11

Assessing Forelimb Function after Unilateral Cervical SCI using Novel Tasks: Limb Step-alternation, Postural Instability and Pasta Handling

Published on: September 16, 2013

Generation of Chimeric Axolotls with Mutant Haploid Limbs Through Embryonic Grafting
07:17

Generation of Chimeric Axolotls with Mutant Haploid Limbs Through Embryonic Grafting

Published on: January 29, 2020

  • Improved quality of life and reduced long-term analgesic requirements are anticipated.
  • Despite substantial initial costs, long-term healthcare needs may be reduced.