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Published on: November 10, 2018
Low-level viremia associated with the use of TaqMan assay
Susan Szabo1, Lee E Moffett, Kelly Cantwell-McNelis
1HIV Community Program, Christiana Care Health System, Wilmington, DE 19899, USA. sszabo@christianacare.org
Abstract:
Poor correlation has been reported between the Roche Cobas AmpliPrep/Cobas (TaqMan) HIV-1 TaqMan assay and the Roche Cobas Amplicor HIV-1 Monitor version 1.5 Amplicor assay. We report 8 patients who experienced unexplained detectable viremia, despite exemplary medication adherence, following a change in viral quantification assay from Amplicor to TaqMan in January 2008. All patients were found to have undetectable HIV RNA by branched DNA (bDNA) assay.
