Serum TSH determinations in pregnancy: how, when and why?

Area of Science:

• Endocrinology
• Reproductive Medicine
• Clinical Chemistry

Background:

• Thyroid dysfunction is common in women of childbearing age.
• Normal thyroid function is vital for a healthy pregnancy outcome.
• Serum TSH assay sensitivity has improved thyroid function testing.

Purpose of the Study:

• To review analytical and clinical aspects of serum TSH determination.
• To highlight the utility of TSH testing in detecting thyroid abnormalities during pregnancy.
• To advocate for universal TSH screening in pregnant women.

Main Methods:

• Review of current literature on serum TSH assays.
• Analysis of TSH's role in diagnosing overt and subclinical thyroid disorders in pregnancy.
• Discussion of clinical implications of thyroid dysfunction in pregnancy.

Main Results:

• Serum TSH is the most sensitive single marker for thyroid function abnormalities.
• Subtle thyroid dysfunction, including overt and subclinical hypothyroidism and hyperthyroidism, can be detected by TSH assays.
• These thyroid disorders are linked to adverse pregnancy outcomes.

Conclusions:

• Serum TSH measurement is a valuable tool for investigating thyroid function in pregnant women.
• TSH testing can identify thyroid abnormalities that may impact pregnancy.
• The authors recommend serum TSH measurement for all pregnant women to ensure optimal outcomes.