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Updated: Jun 12, 2026

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder

Published on: January 9, 2015

Pramipexole and compulsive masturbation.

Randy A Sansone¹, Mark Ferlan

¹Dr. Sansone is a Professor in the Departments of Psychiatry and Internal Medicine at Wright State University School of Medicine in Dayton, Ohio, and Director of Psychiatry Education at Kettering Medical Center in Kettering, Ohio.

Psychiatry (Edgmont (Pa. : Township))

|June 10, 2010

Summary

This summary is machine-generated.

Pramipexole, a dopamine agonist, may cause compulsive behaviors like hypersexual disorder. Discontinuation of pramipexole led to the cessation of compulsive masturbation in a patient.

Keywords:

adverse effects compulsive sexual behavior dopamine agonists hypersexual behavior masturbation

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Area of Science:

Neuroscience
Psychiatry
Pharmacology

Background:

Dopamine agonists are used to treat Parkinson's disease and restless legs syndrome.
Compulsive behaviors are a potential side effect of dopaminergic medications.

Observation:

A case report explored the potential link between pramipexole and compulsive masturbation.
The patient exhibited hypersexual behavior coinciding with pramipexole treatment.

Findings:

A strong association was observed between pramipexole use and compulsive masturbation.
The patient's hypersexual behavior ceased upon discontinuation of pramipexole.

Implications:

Pramipexole, like other dopamine agonists, may trigger compulsive behaviors.
Clinicians should monitor for hypersexual behavior in patients prescribed pramipexole.
This finding contributes to understanding dopamine agonist-induced behavioral changes.