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Updated: Jun 12, 2026

Identification of Orexin and Endocannabinoid Receptors in Adult Zebrafish Using Immunoperoxidase and Immunofluorescence Methods
08:37

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Chemistry and biology of orexin signaling

Thomas Kodadek1, Di Cai

  • 1Departments of Chemistry and Cancer Biology, The Scripps Research Institute, Scripps Florida, Jupiter, FL 33458, USA. Kodadek@scripps.edu

Molecular Biosystems
|June 10, 2010
PubMed

Insights

Orexins are neurohormones regulating crucial functions like feeding and sleep. Understanding orexin signaling is key for developing new drugs targeting these important receptors.

Area of Science:

  • Neuroscience
  • Endocrinology
  • Pharmacology

Background:

  • Orexins are neuropeptides crucial for regulating feeding, sleep-wake cycles, and energy balance.
  • Dysregulation of orexin signaling is implicated in various physiological and neurological disorders.
  • Orexin receptors represent promising therapeutic targets for a range of conditions.

Purpose of the Study:

  • To review recent advancements in understanding orexin signaling pathways.
  • To summarize current pharmacological strategies targeting orexin receptors.
  • To highlight the therapeutic potential of modulating orexin signaling.

Main Methods:

  • Literature review of recent scientific publications.
  • Analysis of studies on orexin receptor pharmacology.
  • Synthesis of data on orexin signaling pathways.

Main Results:

  • Significant progress has been made in elucidating the complex biology of orexin signaling.
  • Several pharmacological approaches to modulate orexin signaling are under active investigation.
  • The development of orexin receptor modulators shows therapeutic promise.

Conclusions:

  • Orexin signaling plays a vital role in numerous physiological processes.
  • Targeting orexin receptors offers a viable strategy for treating various disorders.
  • Continued research is essential for optimizing orexin-based therapeutics.

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