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INVEST study warns on too-low BP in diabetic patients with CAD

J Aalbers

    Cardiovascular Journal of Africa
    |June 10, 2010
    PubMed

    Insights

    Tightening systolic blood pressure below 130 mmHg offers no benefit for hypertensive patients with type 2 diabetes and coronary artery disease. In some cases, this intensive blood pressure lowering can be harmful.

    Area of Science:

    • Cardiology
    • Endocrinology
    • Clinical Trials

    Background:

    • Hypertension management is crucial for patients with type 2 diabetes and coronary artery disease.
    • Previous guidelines suggested intensive blood pressure control for these high-risk populations.

    Purpose of the Study:

    • To evaluate the effect of intensive systolic blood pressure lowering to below 130 mmHg in hypertensive patients with type 2 diabetes and coronary artery disease.

    Main Methods:

    • The INternational VErapamil SR-Trandolapril (INVEST) study was a large, international trial.
    • Participants included hypertensive patients with type 2 diabetes and coronary artery disease.

    Main Results:

    • Intensive systolic blood pressure control below 130 mmHg did not provide additional benefits.
    • This treatment strategy may potentially increase harm in certain patient subgroups.

    Conclusions:

    • Current evidence suggests that a systolic blood pressure target below 130 mmHg is not beneficial for hypertensive patients with type 2 diabetes and coronary artery disease.
    • Less intensive blood pressure targets may be more appropriate for this patient population.

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