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Updated: Jun 12, 2026
Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
Published on: September 6, 2017
[To identify a novel HLA-DRB1 allele in Chinese by sequencing]
Wei Li1, Xiao-yan Shan, Na Liu
1HLA Laboratory, Beijing Red Cross Blood Center, Beijing, 100088 PR China.
Objective:
To identify a novel HLA-DRB1 allele in Chinese.
Methods:
A novel HLA-DR allele was detected by PCR-SSP and SBT in a patient with leukemia.
Results:
The sequence of the novel allele was different from all other known alleles. The novel allele differed from the closet matching allele HLA-DRB1*1404 by one nucleotide substitution in exon 2, at position 33 T>C, this resulted in an amino acid change from Tyr to His at codon 17.
Conclusion:
The novel allele is confirmed as a new HLA allele and it was officially named HLA-DRB1*1461 by WHO Nomenclature Committee in May, 2006.
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