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Related Concept Videos

Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Cancer Cell Migration through Invadopodia01:35

Cancer Cell Migration through Invadopodia

Invadosome is a broad category of cell surface structures with proteolytic activity that  degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However, invadopodia can...
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...

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Related Experiment Video

Updated: Jun 12, 2026

Development of a Human Preclinical Model of Osteoclastogenesis from Peripheral Blood Monocytes Co-cultured with Breast Cancer Cell Lines
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Development of a Human Preclinical Model of Osteoclastogenesis from Peripheral Blood Monocytes Co-cultured with Breast Cancer Cell Lines

Published on: September 13, 2017

Activin A and bone metastasis.

Gaetano Leto1

  • 1Department of Surgery and Oncology, Policlinico Universitario P Giaccone, 90127 Palermo, Italy. gleto@unipa.it

Journal of Cellular Physiology
|June 10, 2010
PubMed
Summary

Activin A (Act A) is a cytokine involved in bone remodeling. Dysregulation of Act A signaling may contribute to bone metastasis, highlighting its potential role in cancer progression.

Area of Science:

  • Biochemistry
  • Cell Biology
  • Oncology

Background:

  • Activin A (Act A) is a cytokine belonging to the transforming growth factor-beta superfamily.
  • Act A regulates critical biological functions, including bone remodeling.
  • Altered bone metabolism and resorption are linked to severe pathological conditions.

Purpose of the Study:

  • To review recent advances in understanding the role of Activin A in bone metastasis pathogenesis.
  • To discuss the implications of these findings for biomedical applications.

Main Methods:

  • Literature review of recent scientific advances.
  • Analysis of the role of Activin A signaling in bone metabolism and metastasis.

Main Results:

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Intra-iliac Artery Injection for Efficient and Selective Modeling of Microscopic Bone Metastasis
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Intra-iliac Artery Injection for Efficient and Selective Modeling of Microscopic Bone Metastasis

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Models of Bone Metastasis
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Models of Bone Metastasis

Published on: September 4, 2012

Related Experiment Videos

Last Updated: Jun 12, 2026

Development of a Human Preclinical Model of Osteoclastogenesis from Peripheral Blood Monocytes Co-cultured with Breast Cancer Cell Lines
06:00

Development of a Human Preclinical Model of Osteoclastogenesis from Peripheral Blood Monocytes Co-cultured with Breast Cancer Cell Lines

Published on: September 13, 2017

Intra-iliac Artery Injection for Efficient and Selective Modeling of Microscopic Bone Metastasis
07:00

Intra-iliac Artery Injection for Efficient and Selective Modeling of Microscopic Bone Metastasis

Published on: September 26, 2016

Models of Bone Metastasis
08:49

Models of Bone Metastasis

Published on: September 4, 2012

  • Deregulation of the activin signaling pathway can disrupt bone metabolism.
  • Evidence suggests Activin A's involvement in the pathogenesis of bone metastasis.
  • Understanding Act A's role opens avenues for therapeutic strategies.

Conclusions:

  • Activin A is implicated in the pathogenesis of bone metastasis.
  • Further research into Act A signaling pathways is crucial for developing targeted therapies.
  • Biomedical applications may arise from understanding Act A's role in bone metastasis.