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Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...

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Related Experiment Video

Updated: Jun 12, 2026

Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification
10:21

Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification

Published on: September 20, 2024

[Primary pulmonary synovial sarcoma confirmed by gene expression analysis].

Seijiro Sato1, Yasuko Hosaka, Kenichi Togashi

  • 1Department of Thoracic Surgery, Japanese Red Cross Nagaoka Hospital, Nagaoka, Japan.

Kyobu Geka. the Japanese Journal of Thoracic Surgery
|June 11, 2010
PubMed
Summary

Gene expression analysis confirmed synovial sarcoma in a lung tumor. This diagnosis was crucial for differentiating it from other mesenchymal tumors, guiding treatment for this rare cancer.

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Last Updated: Jun 12, 2026

Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification
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Area of Science:

  • Oncology
  • Molecular Diagnostics
  • Pulmonary Medicine

Background:

  • Synovial sarcoma is a rare malignant mesenchymal tumor that can occur in various body locations, including the lung.
  • Accurate diagnosis is essential for appropriate patient management and treatment strategies.

Observation:

  • A 39-year-old male presented with left chest pain, leading to the discovery of a lung tumor via chest computed tomography (CT).
  • The tumor involved the lingula and extended to the bronchial bifurcation, necessitating a left pneumonectomy.

Findings:

  • Pathological examination revealed a mesenchymal tumor with small, round, spindle cells, requiring differentiation from peripheral neuroectodermal tumors.
  • Reverse transcription-polymerase chain reaction (RT-PCR) detected the specific SYT-SSX fusion gene, confirming the diagnosis.

Implications:

  • Gene expression analysis, specifically identifying the SYT-SSX fusion, is a definitive method for diagnosing primary pulmonary synovial sarcoma.
  • This case highlights the importance of molecular diagnostics in distinguishing rare lung tumors and informing therapeutic decisions.