Related Experiment Video
Updated: Jun 12, 2026
10:20
Method for Identifying Small Molecule Inhibitors of the Protein-protein Interaction Between HCN1 and TRIP8b
Published on: November 11, 2016
HAT trick: p300, small molecule, inhibitor
1Gladstone Institute of Virology and Immunology, Department of Medicine, University of California, San Francisco, 1650 Owens St., San Francisco, CA 94158, USA. mott@gladstone.ucsf.edu
Chemistry & Biology
|June 11, 2010
Abstract:
p300 is an acetyltransferase that targets histone and nonhistone proteins for lysine acetylation. Based on a p300 structure, Bowers et al. (2010) have conducted an in silico screen for active site small molecule inhibitors of p300. We describe this important discovery and its potential therapeutic applications.
