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Related Experiment Video

Updated: May 13, 2026

In vivo Reprogramming of Adult Somatic Cells to Pluripotency by Overexpression of Yamanaka Factors

In vivo Reprogramming of Adult Somatic Cells to Pluripotency by Overexpression of Yamanaka Factors

Published on: December 17, 2013

Nuclear reprogramming to a pluripotent state by three approaches.

Shinya Yamanaka¹, Helen M Blau

¹Center for iPS Cell Research and Application, Kyoto University, Kyoto 606-8507, Japan.

|June 11, 2010

Summary

Adult cells can be reprogrammed into different cell types, demonstrating significant cellular plasticity. This reprogramming, achieved through various methods, holds promise for future medical applications.

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Area of Science:

Cellular and Molecular Biology
Developmental Biology
Regenerative Medicine

Background:

Stable states of differentiated cells are dynamically controlled and susceptible to perturbation.
Cellular reprogramming allows adult cells to alter gene expression and cell fate.

Purpose of the Study:

To explore the mechanisms and implications of cellular reprogramming.
To highlight the potential medical applications of induced cellular plasticity.

Main Methods:

Nuclear transfer
Cell fusion
Transcription-factor transduction

Main Results:

Demonstrated that 'terminally differentiated' somatic cell nuclei can be reprogrammed.
Showed induced expression of embryonic stem cell genes in reprogrammed somatic cells.
Confirmed the potential for reprogrammed cells to differentiate into various cell types.

Conclusions:

Cellular plasticity is a key feature of differentiated cells, enabling reprogramming.
Experimental approaches like nuclear transfer, cell fusion, and transduction effectively induce reprogramming.
Cellular reprogramming offers significant potential for medical advancements and therapies.