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Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
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[Molecular targeted therapies]

Hideharu Kimura1, Kazuto Nishio

  • 1Department of Genome Biology, Kinki University School of Medicine.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|June 12, 2010
PubMed

Insights

Cancer treatments are evolving beyond chemotherapy to include targeted therapies. Predictive biomarkers are crucial for personalizing cancer care and improving patient outcomes with these new treatments.

Area of Science:

  • Oncology
  • Pharmacogenomics
  • Translational Medicine

Context:

  • Cancer treatment is shifting from traditional cytotoxic chemotherapies to targeted and biological therapies.
  • Targeted therapies are increasingly integrated into standard cancer treatment protocols.
  • Variability in patient response necessitates personalized medicine approaches.

Purpose:

  • To provide a comprehensive overview of molecular targeted agents in cancer therapy.
  • To highlight the role and importance of predictive biomarkers.
  • To discuss novel adaptive clinical trial designs incorporating biomarkers.

Summary:

  • This review examines the evolution of cancer treatment paradigms towards targeted therapies.
  • It emphasizes the critical role of predictive biomarkers in optimizing patient response and guiding personalized medicine strategies.
  • The review also explores innovative clinical trial designs that integrate biomarker discovery and validation.

Impact:

  • Facilitates a deeper understanding of targeted cancer therapies and their associated biomarkers.
  • Informs the development of personalized medicine strategies for improved cancer patient outcomes.
  • Guides the integration of biomarker-driven approaches in future clinical trial designs and cancer care.

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