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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
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Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...

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Related Experiment Video

Updated: Jun 12, 2026

In Vivo Modeling of the Morbid Human Genome using Danio rerio
12:31

In Vivo Modeling of the Morbid Human Genome using Danio rerio

Published on: August 24, 2013

Targeting IL-23 in human diseases.

Mario M D'Elios1, Gianfranco Del Prete, Amedeo Amedei

  • 1University of Florence, Department of Internal Medicine, Viale Morgagni 85, 50134 Florence, Italy.

Expert Opinion on Therapeutic Targets
|June 12, 2010
PubMed
Summary

Interleukin-23 (IL-23) plays a key role in immune responses and disease pathogenesis. Targeting the IL-23 pathway shows promise as a novel therapeutic strategy for autoimmune diseases and cancer.

Area of Science:

  • Immunology
  • Cytokine Signaling
  • Therapeutic Development

Background:

  • Interleukin-23 (IL-23) is a critical cytokine with diverse immunological functions.
  • IL-23 is implicated in host defense mechanisms.
  • Dysregulation of IL-23 contributes to the pathogenesis of various diseases.

Purpose of the Study:

  • To review the emerging role of IL-23 in physiological and pathological conditions.
  • To examine IL-23 pathway-based therapeutic strategies.
  • To assess the efficacy of IL-23 targeting in preclinical and clinical settings.

Main Methods:

  • Literature and patent review focusing on IL-23 pathways.
  • Analysis of therapeutic applications targeting IL-23.
  • Emphasis on findings published within the last five years.

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Last Updated: Jun 12, 2026

In Vivo Modeling of the Morbid Human Genome using Danio rerio
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Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization
03:08

Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization

Published on: October 3, 2025

Main Results:

  • IL-23 is involved in both normal immune functions and disease processes.
  • Various IL-23 pathway-targeting approaches are under investigation for autoimmune diseases and cancer.
  • Preclinical and clinical data demonstrate the potential of IL-23 inhibition.

Conclusions:

  • Targeting IL-23 represents a promising therapeutic strategy.
  • IL-23 inhibition may offer advantages over existing treatments for conditions like psoriasis.
  • IL-23-blocking therapies could be utilized in tailored treatment plans for inflammatory bowel diseases.