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Published on: January 7, 2018
Temporal patterns in overweight and obesity in Type 1 diabetes
B Conway1, R G Miller, T Costacou
1Division of Epidemiology, Vanderbilt University, Nashville, TN, USA.
Summary
Overweight and obesity significantly increased in individuals with Type 1 diabetes over 18 years. Intensive insulin therapy and certain diabetes complications predicted weight changes in this T1DM cohort.
Area of Science:
- Endocrinology
- Metabolic Diseases
- Diabetes Research
Background:
- Time trends of overweight and obesity are known in the general population.
- Temporal patterns of weight gain in Type 1 diabetes (T1DM) are less understood.
Purpose of the Study:
- To assess temporal patterns of overweight and obesity in T1DM.
- To identify predictors of weight change in a T1DM cohort.
Main Methods:
- Study included 589 individuals with childhood-onset T1DM from the Pittsburgh Epidemiology of Diabetes Complications Study.
- Participants were followed biennially for 18 years, with overweight defined as BMI 25.0-29.9 kg/m2 and obesity as BMI >= 30.0 kg/m2.
Main Results:
- Baseline prevalence of overweight and obesity was 28.6% and 3.4%, respectively.
- Over 18 years, overweight prevalence rose by 47% and obesity by sevenfold.
- Intensive insulin therapy increased from 7% to 82%; predictors of weight change included higher HbA1c, autonomic neuropathy, nephropathy, and intensive insulin therapy.
Conclusions:
- Dramatic weight gain observed in T1DM.
- Weight change in T1DM is complex and influenced by multiple factors.
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