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Published on: November 17, 2018
Individual variability of the cutaneous larva migrans (CLM) incubation period
Jean-Yves Siriez1, François Angoulvant, Pierre Buffet
1Assistance Publique - Hôpitaux de Paris, hôpital Robert Debré, Service d'Accueil des Urgences, Paris, France. jean-yves.siriez@rdb.aphp.fr
Abstract:
Whether the high variable incubation period of cutaneous larva migrans depends on the parasite or other host factors remains unknown. Two brothers were contaminated simultaneously, but had 15- and 165-day incubation periods, respectively, suggesting a possible influence of host factors. A long incubation period does not rule out cutaneous larva migrans in patients with creeping eruption.
Insights
The incubation period for cutaneous larva migrans (CLM) varies greatly, possibly due to host factors, not just the parasite. Even a long incubation period doesn't exclude CLM diagnosis in creeping eruption cases.
Area of Science:
- Dermatology
- Parasitology
- Immunology
Background:
- Cutaneous larva migrans (CLM) is a parasitic skin infection caused by hookworm larvae.
- The incubation period of CLM is known to be highly variable, but the underlying reasons are not fully understood.
Observation:
- Two brothers experienced simultaneous exposure to the causative parasite.
- One brother developed CLM with a 15-day incubation period.
- The other brother presented with a significantly longer incubation period of 165 days.
Findings:
- The marked difference in incubation periods between genetically similar siblings suggests that host-related factors play a significant role in CLM development.
- This observation challenges the assumption that parasite load or strain is the sole determinant of CLM onset and duration.
Implications:
- Understanding host factors influencing CLM incubation periods can lead to improved diagnostic approaches.
- A prolonged incubation period should not preclude a diagnosis of CLM in patients presenting with symptoms of creeping eruption.
- Further research into host immunity and environmental factors is warranted to elucidate CLM pathogenesis.
