Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 12, 2026

An “All-laser” Endothelial Transplant
09:59

An “All-laser” Endothelial Transplant

Published on: July 6, 2015

Endonasal laser tissue welding: first human experience.

Benjamin S Bleier1, Noam A Cohen, Alexander G Chiu

  • 1Department of Otorhinolaryngology-Head and Neck Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, USA. bleierb@gmail.com

American Journal of Rhinology & Allergy
|June 12, 2010
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Remission in Global Airway Diseases: EUFOREA Consensus Paper.

Allergy·2026
Same author

Health Locus of Control in Patients with Chronic Rhinosinusitis After Endoscopic Sinus Surgery: A Pilot Study.

American journal of rhinology & allergy·2026
Same author

Novel olfactory cleft computed tomography staging system reveals a trizone anatomic model and biphasic progression in central compartment atopic disease.

The Journal of allergy and clinical immunology·2026
Same author

Delivery of ATSP-7041 by Minimally Invasive Nasal Depot (MIND) to Target Diffuse Intrinsic Pontine Glioma.

Molecular cancer therapeutics·2026
Same author

Formulation considerations in enhancing olfactory mucosal deposition for nose-to-brain drug delivery.

Drug delivery and translational research·2026
Same author

Reply to Correspondence Regarding "Inflammatory Effects of Microplastics and Nanoplastics on Nasal Airway Epithelial Cells".

International forum of allergy & rhinology·2026
Same journal

Clinical Efficacy of Tezepelumab in Moderate-to-Severe Uncontrolled Chronic Rhinosinusitis with Nasal Polyps: A Systematic Review of Randomized Controlled Trials.

American journal of rhinology & allergy·2026
Same journal

Cancer Metastasis to the Sinonasal Cavity: Clinical Characteristics and Survival Analysis in 35 Patients.

American journal of rhinology & allergy·2026
Same journal

Implementation and Outcomes of a Structured Epistaxis Protocol in Hereditary Hemorrhagic Telangiectasia: An Observational Cohort Study from a Multidisciplinary Clinic.

American journal of rhinology & allergy·2026
Same journal

Large-Scale Three-Dimensional CT Mapping of the Frontal Sinus Drainage Pathway: Anatomical Relationships and Surgical Validation.

American journal of rhinology & allergy·2026
Same journal

Comparative Restenosis and Revision Rates of Draf IIB Versus Draf III Frontal Sinusotomy in Chronic Rhinosinusitis: A Meta-Analysis Stratified by Endotype.

American journal of rhinology & allergy·2026
Same journal

Adjuvant Radiotherapy Does Not Improve Overall Survival After Negative Margin Resection of Sinonasal Epithelial-Myoepithelial Carcinoma.

American journal of rhinology & allergy·2026
See all related articles

Laser tissue welding (LTW) offers a safe and effective method for closing wounds in the sinonasal mucosa. This endoscopic technique shows no significant thermal or inflammatory side effects, making it a promising option for skull base surgery.

Area of Science:

  • Minimally Invasive Surgery
  • Biomaterials Science
  • Otolaryngology

Background:

  • Cerebrospinal fluid leak repair is a challenge in endoscopic skull base surgery.
  • Laser tissue welding (LTW) uses a biological solder for watertight wound closure.
  • LTW may be applicable for cranial base reconstruction.

Purpose of the Study:

  • To assess the safety and technical feasibility of endoscopic LTW.
  • To evaluate LTW in human sinonasal mucosa.

Main Methods:

  • Prospective study of 10 patients undergoing endoscopic LTW.
  • Albumin and hyaluronic acid-based solder used for mucosal injury repair.
  • Wound outcomes assessed via endoscopic exam and blinded observer scoring for inflammation, thermal injury, and edema.

More Related Videos

Transcanalicular Diode Laser-assisted Dacryocystorhinostomy for the Treatment of Primary Acquired Nasolacrimal Duct Obstruction
07:30

Transcanalicular Diode Laser-assisted Dacryocystorhinostomy for the Treatment of Primary Acquired Nasolacrimal Duct Obstruction

Published on: October 13, 2017

Laser Nanosurgery of Cerebellar Axons In Vivo
09:25

Laser Nanosurgery of Cerebellar Axons In Vivo

Published on: July 28, 2014

Related Experiment Videos

Last Updated: Jun 12, 2026

An “All-laser” Endothelial Transplant
09:59

An “All-laser” Endothelial Transplant

Published on: July 6, 2015

Transcanalicular Diode Laser-assisted Dacryocystorhinostomy for the Treatment of Primary Acquired Nasolacrimal Duct Obstruction
07:30

Transcanalicular Diode Laser-assisted Dacryocystorhinostomy for the Treatment of Primary Acquired Nasolacrimal Duct Obstruction

Published on: October 13, 2017

Laser Nanosurgery of Cerebellar Axons In Vivo
09:25

Laser Nanosurgery of Cerebellar Axons In Vivo

Published on: July 28, 2014

Main Results:

  • No complications observed in 10 patients followed for an average of 72 days.
  • Solder persisted up to 26 days.
  • No significant differences in inflammation, thermal injury, or edema compared to control wounds.

Conclusions:

  • Endoscopic LTW is a technically feasible and rapid wound closure method.
  • LTW in sinonasal mucosa does not cause significant thermal or inflammatory issues.
  • This technique presents a viable option for endoscopic skull base surgery.