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Published on: April 1, 2019

Association between AT C573T polymorphism and cardiovascular risk factors in myocardial infarction

Maria M Morales-Suarez-Varela1, Concepción Riera-Fortuny, Maria-Luisa Mansego

  • 1Unit of Public Health and Environmental Care, Department of Preventive Medicine and Public Health, University of Valencia, Valencia, Spain. maria.m.morales@uv.es

Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology
|June 12, 2010
PubMed

Insights

The C573T polymorphism in the angiotensin II AT-1 receptor gene is linked to myocardial infarction risk. The CC genotype specifically increases the risk of heart disease, independent of other factors.

Area of Science:

  • Genetics
  • Cardiology
  • Molecular Biology

Background:

  • Polymorphisms in the angiotensin II AT-1 receptor (AT1) gene are implicated in cardiovascular disease pathogenesis.
  • Previous research suggests associations between AT1 gene variants and myocardial infarction (MI).

Purpose of the Study:

  • To investigate the association between two AT1 gene polymorphisms (AT1_1166 and AT1_573) and the risk of ischemic heart disease.
  • To analyze the relationship between these genetic variations and cardiovascular risk factors.

Main Methods:

  • Genotyping of AT1 gene polymorphisms (C573T and A1166C) using polymerase chain reaction and DNA restriction analysis.
  • Comparison of genetic polymorphisms in 174 MI survivors and 182 matched controls.
  • Multivariate analysis adjusting for gender, age, and other risk factors.

Main Results:

  • The A1166C polymorphism showed no significant difference between MI patients and controls.
  • Significant differences in C573T genotypes (CC and TT) were observed between cases and controls.
  • The CC genotype of the C573T polymorphism was identified as a significant risk factor for myocardial infarction, even after adjusting for covariates.

Conclusions:

  • A significant relationship exists between the C573T polymorphism and myocardial infarction pathogenesis.
  • The CC genotype of the C573T polymorphism is a confirmed risk factor for MI.
  • Further research is warranted to elucidate the multifactorial nature of this association.
Abstract

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