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Gonadal and Placental Hormones01:24

Gonadal and Placental Hormones

The gonads, namely the testes in males and the ovaries in females, are pivotal in producing gonadal hormones that orchestrate the intricate processes of sexual development and reproduction.
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair growth — and...

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Possible andrologic markers in elevated neonatal 17-hydroxyprogesterone.

Paolo Cavarzere1, Monica Vincenzi, Rossella Gaudino

  • 1Pediatric Clinic, Department of Mother and Child, University of Verona, Verona, Italy. paolocavarzere@yahoo.it

Fertility and Sterility
|June 12, 2010
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Neonatal infants with high 17-hydroxyprogesterone (17OH-P) show higher inhibin B levels, suggesting potential hypothalamic-pituitary-testis axis alterations. Further follow-up is recommended to monitor their development through childhood and puberty.

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Area of Science:

  • Pediatric Endocrinology
  • Reproductive Endocrinology
  • Neonatal Health

Background:

  • Neonatal screening often identifies infants with elevated 17-hydroxyprogesterone (17OH-P).
  • The implications of elevated neonatal 17OH-P on early endocrine development, particularly the hypothalamic-pituitary-testis (HPT) axis, require further investigation.

Purpose of the Study:

  • To investigate the status of the hypothalamic-pituitary-testis axis in male infants with elevated neonatal 17-hydroxyprogesterone (17OH-P) within the first six months of life.

Main Methods:

  • Prospective analysis of 30 male infants with increased neonatal 17OH-P (patients).
  • Comparison with 52 age-matched healthy control subjects.
  • Measurement of serum testosterone (T), follicle-stimulating hormone (FSH), luteinizing hormone (LH), and inhibin B levels.

Main Results:

  • No significant differences were observed in testosterone (T), FSH, or LH levels between patients and control subjects.
  • Inhibin B levels were significantly higher in male infants with elevated neonatal 17OH-P compared to controls.

Conclusions:

  • Elevated neonatal 17-hydroxyprogesterone (17OH-P) may be associated with altered early reproductive hormone profiles, specifically higher inhibin B.
  • Clinical follow-up of these infants through childhood and puberty is warranted to assess the long-term evolution of their endocrine status and HPT axis function.