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[Normal and pathologic growth of arterial smooth muscle]
1Centre de recherches sur les maladies vasculaires périphériques de l'Association Claude Bernard, hôpital Broussais, Paris.
Archives Des Maladies Du Coeur Et Des Vaisseaux
|January 1, 1991
Abstract:
In addition to contractility, arterial smooth muscle cells, like all connective tissue cells, have a capacity to proliferate and synthesize extracellular matrix. Under different normal (development, aging) and abnormal circumstances (high blood pressure, atherosclerosis, balloon angioplasty), smooth muscle cells express these properties which characterize the dedifferentiated phenotype. This paper reviews the main mechanisms, modulations and possible therapeutic implications of dedifferentiation.