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Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...

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Related Experiment Video

Updated: Jun 12, 2026

Image-guided, Laser-based Fabrication of Vascular-derived Microfluidic Networks

Image-guided, Laser-based Fabrication of Vascular-derived Microfluidic Networks

Published on: January 3, 2017

Three dimensionally flocculated proangiogenic microgels for neovascularization.

Ross J DeVolder¹, Hyun-Joon Kong

¹Department of Chemical & Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

|June 12, 2010

Summary

A novel colloidal gel made from oppositely charged microgels resists displacement in tissue defects. This microparticle drug delivery system enhances regenerative medicine efficacy by improving vascularization and reducing inflammation.

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Last Updated: Jun 12, 2026

Image-guided, Laser-based Fabrication of Vascular-derived Microfluidic Networks

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Micropatterning and Assembly of 3D Microvessels

Micropatterning and Assembly of 3D Microvessels

Published on: September 9, 2016

Area of Science:

Biomaterials Science
Tissue Engineering
Regenerative Medicine

Background:

Microparticles offer advantages for non-invasive drug delivery in tissue engineering.
Implanted microparticles are prone to displacement by mechanical forces, reducing therapeutic effectiveness.

Purpose of the Study:

To develop a drug-encapsulated colloidal gel that resists displacement at implant sites.
To enhance the therapeutic efficacy of microparticle-based drug delivery systems.

Main Methods:

Formed a colloidal gel by mixing negatively charged (poly(ethylene glycol)/poly(sodium acrylate)) and positively charged (poly(ethylene glycol)/poly(vinyl benzyl trimethyl ammonium chloride)) microgels.
Tuned the colloidal gel's structural strength via zeta potential and volumetric ratios.
Encapsulated vascular endothelial growth factor (VEGF) within the colloidal gel for implantation.

Main Results:

The colloidal gel demonstrated resistance to displacement compared to unary microgel suspensions.
Implantation of the VEGF-loaded colloidal gel significantly increased vascular density.
The colloidal gel system effectively limited host inflammation post-implantation.

Conclusions:

A colloidal gel system enhances microparticle drug delivery by improving structural integrity and therapeutic outcomes.
Tuning rheological properties of microparticle suspensions is crucial for effective tissue engineering and drug delivery applications.
This approach offers a promising strategy for designing advanced particulate systems for regenerative medicine.