Percutaneous absorption of mercury vapor by rats

With respect to occupational exposure situations, more information is needed to assess the importance of the skin absorption route for elemental mercury. The purpose of the experiments reported here is to prove the suitability of the rat tail as a model of Hg skin uptake. A vapor generation system used with a tail-only exposure system is described and first results are reported. An Hg uptake via the rat tail skin could be confirmed. The Hg uptake rate cannot be estimated quantitatively by these experiments.