[Changes in the lymph nodes of vaccinated rats after prenatal exposure to an antibiotic]

Changes of anatomical structures and dynamics of cell composition have been studied in lymph nodes of one-month-old rats, vaccinated with typhoid vaccine and sexta-anatoxin, and of rats vaccinated in a similar way, but their mothers have been given tetracycline at early and late periods of pregnancy. After vaccination in 1, 3 and 7 days lymphocytic, blastic, macrophagal, plasmocytic; mast cells, neutrophilic and eosinophilic reactions have been observed in lymph nodes. In the offspring of the rats, that have been given tetracycline during preimplantation and implantation periods (the 1st-7th days of pregnancy) contents of small, middle lymphocytes, plasmocytes, macrophages, mast cells do not change. Neutrophilic and eosinophilic reactions are revealed only in medullary cords, that demonstrates certain inhibition of the immunological function. In the rats, whose mothers have been given tetracycline during embryogenesis (on the 15th-20th days of pregnancy) vaccination results in a considerable increase of the reactive state of the lymph nodes.