[Changes in the anatomic structures and cellular composition of lymph nodes after prenatal exposure to oleandomycin]

Tracheobronchial and mesenteric lymph nodes have been investigated in 120 embryos, fetuses and newborn (5-, 14-, 30-day-old) rats by means of anatomical, histological and electron microscopical methods. Prenatal influence of oleandomycin phosphate on development of lymph nodes has been analysed. Effect of the drug on the mother--fetus system produces certain reactive changes in the anatomical structures responsible for the barrier-filtration and drainage functions of the lymph nodes. The immunocytopoietic function is inhibited, as demonstrates certain decrease of lymphatic line cells.